DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair,With death on the horizon, This will not stop me, Gods call only..........
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contributio
n

Monday, 6 March 2017

Visiting faculty.....SIES college, Chemistry dept, Sion,Mumbai, India





Visiting faculty.....SIES college, Chemistry dept, Sion,Mumbai, India. 04 march 2017.....Service to education is service to God, ThanKs to prin Dr Uma Shankar, Vice principal George Abraham

Saturday, 4 February 2017

Kate Ashton

Kate Ashton
Kate Ashton
Senior Scientist at Amgen, Inc
Amgen
Thousand Oaks, United States
Dr. Kate Ashton received a Masters in Chemistry with Industrial Experience from the University of Edinburgh. She conducted her PhD thesis research on the synthesis and structure elucidation of Reidispongiolide A with Prof. Ian Paterson at the University of Cambridge, and her postdoctoral work on SOMO catalysis with Prof. David W. C. MacMillan at both Caltech and Princeton. 

She has been at Amgen for 6 years and has worked on indications for cancer, Alzheimer’s and diabetes.Dr Fecke works in the area of industrial early drug discovery since 1996. He is currently Group Leader in the Primary Pharmacology department at UCB Pharma (UK) and is involved in the identification and characterization of NCE and NBE drugs in molecular interaction assays for both immunological and CNS diseases. 

Prior to joining UCB, he worked for Novartis and Siena Biotech in the areas of transplant rejection, neurodegeneration and oncology. He obtained his PhD at the Heinrich-Heine-University Dusseldorf in Germany in 1994.



Image result for amg 3969

AMG-3969

M.Wt: 522.46
Cas : 1361224-53-4 , MF: C21H20F6N4O3S
WO 2012027261 PRODUCT PATENT
                   Kate AshtonMichael David BartbergerYunxin BoMarian C. BryanMichael CroghanChristopher Harold FotschClarence Henderson HaleRoxanne Kay KunzLongbin LiuNobuko NishimuraMark H. NormanLewis Dale PenningtonSteve Fong PoonMarkian Myroslaw StecJean David Joseph St., Jr.Nuria A. TamayoChristopher Michael TegleyKevin Chao Yang

Amgen Inc.
2-[4-[(2S)-4-[(6-Amino-3-pyridinyl)sulfonyl]-2-(1-propyn-1-yl)-1-piperazinyl]phenyl]-1,1,1,3,3,3-hexafluoro-2-propanol)


MAKING CONNECTIONS Aleksandra Baranczak (right), a fourth-year grad student in Gary A. Sulikowski’s lab at Vanderbilt University, discusses her efforts to synthesize the core of the diazo-containing natural product lomaiviticin A with Kate Ashton, a medicinal chemist at Amgen

Experience

Senior Scientist

Amgen, Inc.
 – Present (9 years 5 months)

Postdoctoral Fellow

Princeton University
 –  (7 months)

Postdoctoral Fellow

California Institute of Technology
 –  (1 year 7 months)

Research Associate

Merck, UK
 –  (1 year 4 months)

Education

University of Cambridge

Doctor of Philosophy (PhD), Organic Chemistry

Edinburgh University

Masters with Industrial Experience, Organic Chemistry
///////////

Tuesday, 3 January 2017

Dr. Kurt Stoeckli, President & Chief Scientific Officer, Glenmark Pharmaceuticals ltd

Kurt Stoeckli

Dr. Kurt Stoeckli

President & Chief Scientific Officer
Glenmark Pharmaceuticals ltd
Neuchatel, Switzerland

Links


Having spent more than two decades in the pharmaceutical arena, Dr. Stoeckli has extensive industry experience and joins us from Sanofi where he was Group Vice President for Global Bio Pharmaceuticals Division. He was on their R&D Board, and served as CSO for R&D, France. In his tenure of more than fifteen years with Sanofi he has held progressive leadership positions of – Vice President, Global Head of Therapeutic Unit -Immuno-Inflammation, Vice President - Biological Sciences & Scientific Site Director, Vice President of Biological Sciences, Member of the Sanofi Aventis Discovery Board, Global Head of Discovery Technologies, and lastly Vice President, Global Lead Discovery, Aventis Pharma. Prior to joining Sanofi, Dr. Stoeckli worked for seven years in drug discovery at Novartis/Sandoz in Basel, Switzerland.
Dr. Stoeckli is Postdoctoral Fellow & Assistant Professor from Department of Biochemistry & Biophysics, University of California Medical Center and Ph.D., Cell Biology & Neurosciences from Max-Planck-Institute for Neurobiology.

Experience

Image result for glenmark
President & Chief Scientific Officer
Glenmark Pharmaceuticals ltd
Neuchatel, Switzerland
oct 1 2016.............


Vice President Global Biotherapeutics

SANOFI
 – Present (4 years)Paris Area, France
Global responsibility within R&D for biologics from discovery up until phase 3 support across therapeutic areas


Deputy to President of Global R&D (ad interim) for Research & Early Development

Sanofi
 –  (7 months)Paris Area, France
Global R&D Management


VP R&D Global Head Immuno-Inflammation Unit

sanofi-aventis
 –  (2 years 3 months)Paris - Bridgewater
Therapeutic area head (Research & Early Development) in the area of immune-mediated and chronic inflammatory diseases


Vice President Biological Sciences & Scientific Director Vitry-Alfortville-Evry Site

Sanofi
 –  (1 year)Paris Area, France
Global head of research biologics
Member of R&D board
Scientific Director of Vitry-Alfortville-Evry Site


VP Biological Sciences, Discovery Research

sanofi-aventis
 –  (1 year 5 months)Frankfurt Am Main Area, Germany
Responsibility for newly created research biologics with teams in Frankfurt, Paris, Toulouse, Bridgewater, Cambridge)


VP Lead Discovery Technologies

Sanofi Aventis
 –  (7 years 6 months)Frankfurt Area, Germany


Research Program Head

Novartis AG
 –  (7 years 3 months)Basel Area, Switzerland

Education



Max Planck Society

 


Universität Basel

Doctor of Philosophy (Ph.D.)


INSEAD

 
2001

Sunday, 25 December 2016

Reflections on Chirality in the Pharmaceutical Industry: Past, Present and Future Dr. Christopher J. Welch, Distinguished Scientist Process Research & Development Merck Research Laboratories, USA


Image result for Christopher J. Welch
New Technologies, Postdoc Program, Science Lead, Analytical Chemistry at Merck
Reflections on Chirality in the Pharmaceutical Industry: Past, Present and Future Dr. Christopher J. Welch, Distinguished Scientist Process Research & Development Merck Research Laboratories, USA   





A PRESENTATION
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At Chiral India 2016, New horizons in Drug development, Harnessing the power of Chirality .Organised by chemical weekly at Holiday inn international, Mumbai, India, Nov 8 2016



Christopher J. Welch

Science Lead for Analytical Chemistry
Merck Research Laboratories
Christopher J. Welch is Science Lead for Analytical Chemistry within the Process and Analytical Chemistry area at Merck Research Laboratories in Rahway, NJ.  Chris leads the New Technologies Review and Licensing Committee (NT-RLC), the organization that oversees identification, acquisition and evaluation of new technologies of potential value to Merck Research Laboratories.  Chris also leads the MRL Postdoctoral Research Fellows Program.  He received his BS degrees in Chemistry and Biochemistry from the University of Illinois at Urbana-Champaign in 1982 and a Ph.D. degree in Organic Chemistry (also U of I) in 1992. Dr. Welch has worked in a variety of fields within the chemical industry, including discovery synthesis of agrochemicals (Velsicol-Sandoz), development of reagents for improved immunodiagnostic assays (Abbott Laboratories), and development and commercialization of chromatographic stationary phases, reagents and enantioselective catalysts within a small chemical business environment (Regis Technologies).  Since joining Merck in 1999, he has focused on developing and applying improved methods and equipment for purification, synthesis and analysis of pharmaceuticals and intermediates.  Dr. Welch has authored more than 230 scientific publications and patents.  He is co-founder of the journal, Enantiomer, a current or past member of the editorial advisory boards for the journals, Chirality, Organic & Biomolecular ChemistryJournal of the Korean Chemical SocietyChemistry WorldChemical & Engineering News and ACS Central Science.  Chris is past chair of the ACS Division of Organic Chemistry (ORGN), a member of the Executive Committee for the International Symposia on Chirality, a member of the ACS steering committee for Pacifichem and a member of the PittCon Program Resource Team.  Honors and awards include the NJCG Award for Excellence in Chromatography (2004), the PACS Activated Carbon Hall of Fame award (2007), MRL Presidents Award for Environmental Achievement (2009), Microsoft Life Science Innovation Award (2010), Fellow of the American Chemical Society (2010), Fellow of the American Association for the Advancement of Science, AAAS (2013), the Chirality Medal (2015) and the University of Nebraska Industrial Advisory Board Award (2016).

Experience




Distinguished Scientist, Process & Analytical Chemistry

Merck & Co., Inc.
– Present (17 years 8 months)Rahway, NJ
Current responsibilities: Scientific Lead, Analytical Chemistry co-chair, New Technologies Review & Licensing Committee (NT-RLC) co-chair, Merck Research Laboratories Postdoctoral Research Fellows Committee
Previous Positions at Merck: Science Lead, Global Analytical Chemistry 8/10 – 8/12 Distinguished Senior Investigator, Process Research 7/07 – 8/10 Associate Director. Process Research 1/06 – 6/07 Senior Research Fellow, Process Research 6/03 – 12/05 Research Fellow, Process Research 5/99 – 6/03

Director of Research

Regis Technologies
(6 years 11 months)Morton Grove, IL (Chicago area)
- New product development and commercialization (chromatography columns, reagents, enantioselective catalysts) - Scientific evaluation of custom organic synthesis business - Set up contract synthesis/preparative chromatographic separation business - first of kind

Honors & Awards

Fellow

American Association for the Advancement of Science (AAAS)

Fellow

American Chemical Society (ACS)

Chirality Medal 2015

Presidential Green Chemistry Award

US Environmental Protection Agency

– for precompetitive collaboration between Merck, Pfizer, Eli Lilly and University of Wisconsin on Aerobic Oxidation Methods for Pharmaceutical Synthesis - co-awardees: Shannon Stahl and Thatcher Root (U. Wisconsin), Joel Hawkins (Pfizer) and Joe Martinelli (Lilly)

Industrial Advisory Board (IAB) Award

University of Nebraska Department of Chemistry

Inaugural IAB award from U. Nebraska recognizing excellence in scientific research in an industry setting

Christopher J Welch

Organizations



American Chemical Society, Division of Organic Chemistry (ORGN)

Councilor and Chair

Pacifichem

Member of Steering Committee for Pacifichem 2020
Starting



Chirality (Journal)

member, editorial board
Starting

Chemical & Engineering News

member, editorial advisory board
Starting

Chemistry Today (RSC)

member, editorial advisory board
Starting



Journal of the Korean Chemical Society

member, international advisory board
Starting

Pittcon

Member, Pittcon Program Committee Resource Team
Starting

ACS Central Science

Member of Editorial Advisory Board
Starting



American Chemical Society

Member, Committee on Science (ComSci
Starting

Image result for Christopher Welch MERCK

Publications

2014 publications, part 1

Use of a Miniature Mass Spectrometer to Support Pharmaceutical Process Research Investigations, Org. Proc. R&D 18, 103-108, 2014.
Chromatographic Separation and Assignment of Absolute Configuration of Hydroxywarfarin Isomers, Chirality 26, 95-101, 2014. Chromatographic Resolution of Closely Related Species in Pharmaceutical Chemistry: Dehalogenation Impurities and Mixtures of Halogen...more



2014 publications - part 2


Precompetitive Collaboration on Enabling Technologies for the Pharmaceutical Industry, Org. Proc. R&D 18, 481–487, 2014.
Imine-based Chiroptical Sensing Approach for Analysis of Chiral Amines: From Method Design to Synthetic Application, Chem. Sci. 5, 2855-2861, 2014. Advances in Achiral Stationary Phases for SFC, Amer. Pharm. Rev., April 2014, 36-41. Liquid Chromatography Methods for...more

2013 Publications

Evaluation of core–shell particle columns for ion-pair reversed-phase liquid chromatography analysis of oligonucleotides, J. Pharm. Biomed. Anal. 72, 25–32, 2013.
Pharmaceutical Industry Practices on Genotoxic Impurities, in Pharmaceutical Industry Practices on Genotoxic Impurities, ed Heewoon Lee, Taylor & Francis, 2013. Rapid Analysis of Residual Palladium in Pharmaceutical...more

2012 Publications
2012
A Simple Parallel Gas Chromatography Column Screening System, Wes Schafer, Simon E. Hamilton, Zainab Pirzada and Christopher J. Welch, Chirality, 24,1–4, 2012.
Rapid catalyst identification for the synthesis of the pyrimidinone core of HIV integrase inhibitors, A. Bellomo, N. Celebi-Olcum, X. Bu, N. Rivera, R.T. Ruck, C.J. Welch, K.N. Houk, S.D. Dreher, Angew. Chem. Int. Ed., 51 (2012) 1-5 ...more

2011 Publications

Application of Ion Mobility Spectrometry in Drug Substance Development, H. Gao, X. Jia, R. Xiang, X. Gong, C. Welch, Analytical Methods, 3, 1828-1837, 2011.
Analytical Method Volume Intensity Index:A Green Chemistry Metric for HPLC Methodology in the Pharmaceutical Industry, R. Hartman, R. Helmy, M. Al-Sayah, C. Welch, Green Chemistry 13, 934-939, 2011. Does an Axial Propeller Shape on a...more

2010 Publications

High-throughput metal screening in pharmaceutical samples by ICP-MS with automated flow injection using a modified HPLC configuration, Tu, Wang, Welch, J. Pharm. Biomed. Anal., 51, 90-95, 2010.
Systematic Evaluation of New Chiral Stationary Phases for Supercritical Fluid Chromatography Using a Standard Racemate Library, Pirzada, Personick, Biba, Gong, Zhou, Schafer, Welch, J. Chromaogr.A,...more

Adsorbent Screening for Metal Impurity Removal in Pharmaceutical Process(Link)

Organic Process Research & Development
February 23, 2005
A microtube screening approach affords simple and convenient assessment of the selective adsorption of metal impurities by a variety of different process adsorbents. This approach is helpful in identifying rapid solutions to metal impurity problems in pharmaceutical process research. Several examples illustrating the utility of the approach are presented.
Online Analysis of Flowing Streams Using Microflow HPLC

Journal of Pharmaceutical and Biomedical An
Response to Comment on “Cocktail Chromatography: Enabling the Migration of HPLC to Nonlaboratory Environments”(Link)

ACS Sustainable Chem. Eng. 2015, 3 (9), 1897.

ACS Sustainable Chem. Eng. 2015, 3 (9), 1897.
Education

University of Illinois at Urbana-Champaign
The University of Chicago





Image result for Christopher Welch MERCK
FUELING INNOVATION
Welch helped launch Merck's new postdoctoral research fellowship program.







/////////Reflections on Chirality in the Pharmaceutical Industry, Past, Present and Future Dr. Christopher J. Welch, Distinguished Scientist, Process Research & Development,  Merck Research Laboratories, USA, presentation