DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair,With death on the horizon, This will not stop me, Gods call only..........
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contributio
n

Wednesday 25 February 2015

Dr. Srivari Chandrasekhar


Chief Scientist & Head, Division of Natural Products Chemistry, CSIR- Indian Institute of Chemical Technology
Chandrasekhar obtained his Bachelor’s and Master’s degrees in 1982 and 1985 respectively, from Osmania University, Hyderabad and excelled in the same with distinction. He then joined A. V. Rama Rao’s group at CSIR–IICT and earned his doctorate in 1991, also from Osmania University. Between 1991 and 1994 he was associated with J. R. Falck (University of Texas Southwestern Medical Center) as a postdoctoral student. In 1994, Chandrasekhar joined his parent institute (CSIR–IICT) as a scientist

Director 
CSIR-Indian Institute of Chemical Technology                              
(Council of Scientific and Industrial Research)
Ministry of Science & Technology, Government of India
Tarnaka, Hyderabad-500007, Telangana, INDIA 



Landline27193030
Mobile+919440802787
Fax
Email IDdirector@iict.res.in

Council of Scientific and Industrial Research
Ministry of Science and Technology, Government of India

CSIR-IICT
CSIR-Indian Institute of Chemical Technology






http://www.iictindia.org



ICOS21 at IIT-Bombay ..Mumbai, India,. An International conference on Organic chemistry....Day one...11 dec 2016, A chance to meet, DR SRIVARI CHANDRASEKHAR, Director IICT Hyderabad





Chandrasekhar obtained his Bachelor’s and Master’s degrees in 1982 and 1985 respectively, from Osmania University, Hyderabad

After obtaining a Ph.D. under the supervision of Dr. A. V. Ramarao at the Indian Institute of Chemical Technology, Hyderabad,
DR AV RAMA RAO


He moved to theUniversity of Texas Southwestern Medical School for post-doctoral research with Professor J. R. Falck
Professor J. R. Falck

and
then to the University of Goettingen, Germany as Alexander von Humboldt Fellow in the group of Professor L. F. Tietze.
 Professor L. F. Tietze

His research interests include the synthesis of marine natural products, peptides and peptidomimetics, combinatorial chemistry and new solvent media for organic synthesis.
He is a recipient of a Young Scientist award of the Indian National Science Academy, B M Birla Science Prize and National Academy of Sciences-Reliance Industries Platinum Jubilee Award. He has over 190 publications, 2 patents, and guided 20 students for their Ph.D. degrees.


According to a press release here on Tuesday, Dr. Chandrasekhar has been conferred the honour for his significant contribution in organic chemistry and medicinal chemistry.
The major contributions include synthesis of complex natural products, especially of marine origin with anti-cancer and anti-depressant properties, green chemistry and automation chemistry to make large number of new chemicals.
He has produced 25 Ph.D. students and published more than 200 papers in international journals. He is also a fellow of National Academy of Sciences.
Image result for srivari chandrasekhar
India has achieved many prizes in 2014. Before the year ends IICT scientist Srivari Chandrasekhar has added one more prize, he wins Infosys Prize. The scientist who has made important contributions in potential drug developments. Srivari Chandrasekhar from CSIR-IICT , Hyderabad, was announced the winner of the Infosys Prize 2014 in Physical Sciences. The award includes a purse of Rs. 55 lakh, a 22 carat gold medal and citation. The award will be presented by The President on January 5 in Kolkata. The prize is awarded annually by the Infosys Foundation.
He had won the CSIR Technology award-2014 along with his team member
Chandrasekhar’s current contribution is to develop a technology for manufacturing Misoprostal, an abortive drug also used in the treatment of ulcers. Now we can easily get rid of Ulcer.
He has successfully prepared some important drug molecules such as bedaquiline for multi-drug resistant TB, Galantamine for Alzheimer’s disease, Sertraline for treatment of depression, Nebivolol for hypertension and marine natural products such as Eribulin, Azumamide, Arenamide and Bengazole which are scarce to get from nature, with potent biological activities.
As he moves on achieving his target , he has made contributions in synthesizing complex and scarcely available natural products in the laboratory using easily available chemicals.
Chandrasekhar has over 250 publications in national and international journals to his credit.
Prof. Chandrasekhar has displayed an exceptional flair for identifying and synthesizing molecules of biological relevance, topical synthetic interest and utility to industry. His research efforts, with an impressive degree of innovations and enterprise, have led to the synthesis of complex and scarcely available natural products and new molecular entities for affordable healthcare. His endeavors have provided cost-effective technologies to chemical industry through identification of new reagents / solvents for specific transformations. Chandrasekhar's group has synthesized several classes of complex natural products in optically pure form employing chiral pool precursors and catalytic asymmetric reactions and his syntheses of pladienolide, azumamide, bengazole etc., bear testimony to the efficacy of such approaches.

His passion and commitment to topical health related problems is through provisioning for better and affordable access to important drugs. Mention may be made of hissynthesis of bedaquiline, the first drug approved by FDA after a gap of over 40 years for the treatment of multi-drug resistant TB through simpler transformations and higher yields to ensure ready availability. He along with a team atIICT has developed a scalable synthetic route for misoprostol (a hormone like biologically important synthetic prostaglandin) used to prevent gastric ulcer, induce labor and / or abortion (particularly for safe termination of unwanted pregnancies), which has already been commercialized.
More prudent research field has been the identification of novel peptido-mimetics wherein research group of Dr. S. Chandrasekhar has synthesized β-sugar amino acids, norbornene-based, aminoxy acids of furanoses and nucleoside-based amino acids and demonstrated that these monomers in various combinations of oligomerization resulted in predefined secondary structures including nanotubes.
Dr S. Chandrasekhar has for the first time identified polyethylene glycol (PEG) as a recyclable solvent for organo-metallic reactions wherein both the solvent and catalyst can be recycled. This unprecedented report triggered various research programs using PEG as a solvent in different parts of the world. Some of the reactions worth mentioning using PEG as solvent are as follows: Heck reaction in PEG, Sharpless asymmetric dihydroxylation (was performed for the first time in PEG), PtO2 recycle and H2 absorption studies. This work has found direct applications in developing non-infringing technologies for APIs.
Dr S Chandrasekhar has never hesitated to take-up challenging process development subjects relevant to health care. The processes developed for semi-synthesis of Taxol (M/s. Cipla), Misoprostol (M/s. AVRA) and Carboprost (M/s. AVRA) are worth mentioning and biotech problems are also addressed by him as evident in the synthesis of Fondaparinux as anti-coagulant agent (Table 1). In addition, as part of the ‘Drug Discovery Process,’ over 500 new chemical entities are being synthesized in his group. The process developed for EV-077 sponsored by M/s. Evolva biotech helped them to enter into phase I clinical studies.

Several combinatorial libraries were prepared in his group as new chemical entities for screening against cancer (US patent 7179937), TNFα, 5HT antagonism etc. Two review articles written by him on hybrid natural products (Angewandte Chemie 2003, 3996) and prostaglandins (Chemical Review, 2007, 3286) are worth mentioning. A recent contribution of Dr. S. Chandrasekhar is the synthesis of bedaquiline (2S)-R207910, a novel anti-tuberculosis molecule, which has appeared as cover page with theme “Chemistry for a healthy world” in Eur. J. Org. Chem. 2011, 2057.

Education
Alexander von Humboldt Fellow in Organic Chemistry during 2001 from University of Goettingen, Germany;
Post Doctoral studies in Organic Chemistry during 1991-1994 from UT Southwestern Medical Center, Dallas, TX
Ph.D in Organic Chemistry during 1991 from Osmania University
(work done at IICT, Title:Synthesis of Some Biologically Active Compounds; Supervisor: Dr. A. V. Rama Rao, D. Sc., FNA, FTWAS)
M.Sc in Organic Chemistry during 1985 from Osmania University
B.Sc in Botany, Zoology, Chemistry during 1982 Osmania University

Employment
Junior Research Fellow from 1986 to 1988 at Indian Institute of Chemical Technology, Hyderabad;
Senior Research Fellow from 1988 to 1991 at Indian Institute of Chemical Technology, Hyderabad;
Post Doctoral Fellow from 1991 to 1994 at University of Texas, South western Medical Center, Dallas, USA;
Scientist C from 1994 to 1999 at Indian Institute of Chemical Technology, Hyderabad;
Scientist EI from 1999 to 2004 at Indian Institute of Chemical Technology, Hyderabad;
Alexander von Humboldt Fellow from 2000 to 2001 at University of Goettingen, Germany;
Scientist EII from 2004 to 2005 at Indian Institute of Chemical Technology, Hyderabad;
Scientist F from 2005 to 2010 at Indian Institute of Chemical Technology, Hyderabad;
Scientist G, Chief Scientist from 2010 to 2015 at Indian Institute of Chemical Technology, Hyderabad;
Director, from June 2015 at Indian Institute of Chemical Technology, Hyderabad;


PATENTS

  1. International patent, Gurjar, Mukund K.; (Pune, IN) ; Wakharkar, Radhika D.; (Pune, IN) ; Desiraju, Gautam R.; (Hyderabad, IN) ; Nangia, Ashwini; (Hyderabad, IN) ; Yadav, J. S.; (Hyderabad, IN) ; Burman, Anand C.; (Ghaziabad, IN) ; Mukherjee, Rama; (Ghaziabad, IN) ; Borate, Hanumant Bapurao; (Pune, IN) ; Chandrasekhar, Srivari; (Hyderabad, IN) ; Jaggi, Manu; (Ghaziabad, IN) ; Singh, Anuo T.; (Ghaziabad, IN) ; Kapoor, Kamal K.; (Ghaziabad, IN) ; Sarkhel, Sanjay; (Hyderabad, IN) ; Sairam, Kalapatapu V.V.M.; (Hyderabad, IN) US 7179937. Cyclopentenone derivatives for cancer therapy.
  2. Saibal Das, Rene Gree, J. S. Yadav, S. Chandrasekhar, P Srihari and A.V. Rama Rao. (Application no:1530/CHE/2007, Filing date: 16.07.07, Indian patent filed). Process for enzymatic resolution of racemic monosubstituted cis-2-cycloalkene-1,4-diols in ionic liquids.
  3. S.Chandrasekhar, T. Pavan Kumar, Vidyavathi Patro and Ch. Rajireddy. (Patent submitted to IICT IPM Division). Novel triazoles andoxime ethers from hydroxylamine derivatives.


PUBS
  1. Enantioselective synthesis of Pladienolide B and truncated analogues as new anti-cancer agents V Praveen Kumar and S. Chandrasekhar* Organic Letters 2013, 15, 3610-3613
  2. Formal Synthesis of Anti-Platelet Drug, Beraprost N. Kesava Reddy, B. V. D. Vijaykumar and S. Chandrasekhar* Organic Letters 2012, 14, 299-301
  3. Total Synthesis of Bengazole A S. Chandrasekhar,* and A. Sudhakar Organic Letters 2010, 12, 236-238
  4. Polyethylene glycol (400) as superior solvent medium against ionic liquids for catalytic hydrogenations with PtO2 S. Chandrasekhar,* S. Jaya Prakash and Ch. Lohitha Rao J. Org. Chem. 2006, 71, 2196-2199
  5. Expanding the Conformational Pool of cis-β-Sugar Amino Acid: Accommodation of β-hGly Motif in Robust 14-Helix S. Chandrasekhar,* M. Srinivasa Reddy, B. Nagendra Babu, B. Jagadeesh, A. Prabhakar and B. Jagannadh. J. Am. Chem. Soc. 2005, 127, 9664-9665

Srivari Chandrasekhar

Srivari ChandrasekharPhysical Sciences, 2014
Affordable drugs using clean green methods
Affordable drugs using clean green methods
View Infographic
Srivari Chandrashekar
Chief Scientist and Head, Division of Natural Products Chemistry, CSIR‑Indian Institute of Chemical Technology, Hyderabad, India
The Infosys Prize 2014 in Physical Sciences is awarded to Dr. S. Chandrasekhar for his diverse and notable contributions in synthetic organic chemistry with special focus on the synthesis of complex molecules from natural sources. He has devised innovative, practical approaches to pharmaceuticals of current interest to industry.

Congratulatory Message From The Jury Chair – Shrinivas Kulkarni

Congratulations Srivari for winning the 2014 Prize in Physical Sciences. Your work was impressive not only in the breadth of chemistry it covered but also for its impact on society. In fact your approach of concept to commercialization or ‘bench to bed’ is truly unique for academic scientists in the Indian context. Not only has your work had important ramifications in chemistry but it will affect branches of society such as drugs and pharmaceuticals; agro chemicals and materials. Congratulations again.

Bio

Dr. Srivari Chandrasekhar is Chief Scientist and Head, Division of Natural Products Chemistry at the Indian Institute of Chemical Technology (IICT). He received his B.Sc. (1982), M.Sc. (1985) and Ph.D. (1991) degrees from Osmania University, and pursued post-doctoral research at the UT Southwestern Medical Center, Dallas, USA, with Prof. J. R. Falck. As a Humboldt Fellow at the University of Göttingen, he worked on the synthesis of hybrid natural products with Prof. L. F. Tietze.
Chandrasekhar was instrumental in setting up the state-of-the-art Molbank facility at the IICT for the storage and retrieval of chemical samples for HT screening.
He has over 240 publications in national and international journals. He has mentored a large number of doctoral and post-doctoral students and won several awards, including the INSA medal for Young Scientists, CSIR Young Scientist Award, AVRA Young Scientist Award, and the FAPCCI award.
He and his team won the CSIR Technology Award, 2014 for commercializing the process for misoprostol. He is a Fellow of the Indian Academy of Sciences, Bangalore, the National Academy of Sciences, Allahabad, and the Indian National Science Academy, New Delhi.

Scope And Impact Of Work

Dr. S. Chandrasekhar has displayed a flair for identifying and synthesizing molecules of biological relevance, topical synthetic interest and utility to industry. His research efforts, with an impressive degree of innovation and enterprise, have led to the synthesis of complex and scarcely available natural products and new molecular entities for affordable healthcare. His endeavors have provided cost-effective technologies to the chemical industry through the identification of new reagents / solvents for specific transformations.
Chandrasekhar's group has synthesized several classes of complex natural products in optically pure form employing chiral pool precursors and catalytic asymmetric reactions and his syntheses of pladienolide, azumamide and bengazole bear testimony to the efficacy of such approaches.
His passion and commitment to topical health-related problems is evident in his provisioning for better and affordable access to important drugs. This includes his synthesis of bedaquiline, the first drug approved by FDA in over 40 years for the treatment of multidrug-resistant TB. His team at IICT has developed a scalable synthetic route for misoprostol (a hormone-like biologically important synthetic prostaglandin), used to prevent gastric ulcer, induce labor and / or safely terminate unwanted pregnancies, and this has already been commercialized.
Chandrasekhar has developed methodologies and reagents which help in achieving the synthesis of structurally complex bio-actives in lesser number of steps and avoid the use of hazardous solvents. His contribution in this area has been the promotion of PEG (polyethyleneglycol) as an eco-friendly solvent for processing and recycling expensive metal catalysts based on Palladium, Osmium and Ruthenium in diverse reactions. This work has inspired researchers worldwide to use PEG.
Chandrasekhar has mentored many doctoral and post-doctoral students and is recognized as an inspirational leader among the young generation. His research has drawn the attention of pharma and chemical companies in India and helped enhance their competitiveness.

Citation By The Jury

Dr. Chandrasekhar's group has synthesized over 30 complex natural products and developed several processes to provide better and affordable access to important drugs. Among these is bedaquiline, the first drug approved by FDA in over 40 years for the treatment of multidrug-resistant TB, which Dr. Chandrasekhar has synthesized through simpler transformations and higher yields to make it affordable and accessible.
He, along with his team, has developed a scalable synthetic route for misoprostol (a hormone similar to biologically important synthetic prostaglandin). This is used to prevent gastric ulcer, induce labor and / or safely terminate unwanted pregnancies. This has already been commercialized.

HDr. Chandrasekhar has mentored a large number of doctoral and post-doctoral students and is recognized as an inspirational leader among the young generation. His research has drawn the attention of pharma and chemical companies in India and helped many of them enhance their competitiveness.

Paper

Total synthesis of a thromboxane receptor antagonist, terutroban

Org. Biomol. Chem., 2015, 13,2951-2957
DOI: 10.1039/C4OB02302A, Paper

*Corresponding authors
aDivision of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India 500 007
E-mail: srivaric@iict.res.in;
Fax: +91-40-27160152 ;
Tel: +91-40-27193210, 27193434
bAcademy of Scientific and Innovative Research, New Delhi, India
Org. Biomol. Chem., 2015,13, 2951-2957
DOI: 10.1039/C4OB02302A


Image result for IICT






Join me on Linkedin

View Anthony Melvin Crasto Ph.D's profile on LinkedIn

Join me on Facebook FACEBOOK
Join me on twitterFollow amcrasto on Twitter     
Join me on google plus Googleplus

 amcrasto@gmail.com



Monday 23 February 2015

Dr. D. Srinivasa Reddy of NCL winner Shanti Swarup Bhatnagar Award 2015

ds.reddy

Dr. D. Srinivasa Reddy
Senior Scientist
Organic Chemistry Division
National Chemical Laboratory
PUNE, INDIA

LINKS
 

 NCL PUNE INDIA

 WEBSITE--http://www.ncl-india.org/



Dr. Srinivasa Reddy of CSIR-NCL bags the 

prestigious Shanti Swarup Bhatnagar Prize



The award comprises a citation, a plaque, a cash prize of Rs 5 lakh
dr













The Shanti Swarup Bhatnagar Prize for the year 2015 in chemical sciences has been awarded to Dr. D. Srinivasa Reddy of CSIR-National Chemical Laboratory (CSIR-NCL), Pune for his outstanding contributions to the area of total synthesis of natural products and medicinal chemistry.
This is a most prestigious award given to the scientists under 45 years of age and who have demonstrated exceptional potential in Science and Technology. The award derives its value from its rich legacy of those who won this award before and added enormous value to Indian Science.
Dr. Reddy will be bestowed with the award at a formal function, which shall be presided over by the honourable Prime Minister. The award, named after the founder director general of Council of Scientific & Industrial Research (CSIR), Dr. Shanti Swarup Bhatnagar, comprises a citation, a plaque, a cash prize of Rs 5 lakh.
Dr. Reddy's research group current interests are in the field of total synthesis and drug discovery by applying medicinal chemistry. He has also been involved in the synthesis of the agrochemicals like small molecules for crop protection. The total synthesis of more than twenty natural products has been achieved in his lab including a sex pheromone that attracts the mealy bugs and has potential use in the crop protection. On the medicinal chemistry front significant progress has been made by his group using a new concept called "Silicon-switch approach" towards central nervous system drugs. Identification of New Chemical Entities for the potential treatment of diabetes and infectious diseases is being done in collaboration with industry partners.
His efforts are evidenced by 65 publications and 30 patents. He has recently received the NASI-Reliance industries platinum jubilee award-2015 for application oriented innovations and the CRSI bronze medal. In addition, he is also the recipient of Central Drug Research Institute award for excellence in the drug research in chemical sciences and scientist of the year award by the NCL Research Foundation in the year 2013. Dr. Reddy had worked with pharmaceutical companies for seven years before joining CSIR-NCL in 2010.




AN INTRODUCTION

Ph.D., University of Hyderabad, 2000 (Advisor: Professor Goverdhan Mehta).

Post-doctoral with Profs. Sergey A. Kozmin(University of Chicago, USA) and Prof.
Jeffrey Aubé (University of Kansas, USA)

Experienced in leading drug discovery programs (Dr. Reddy’s & TATA Advinus – 7
years of pharma experience)

Acquired skills in designing novel small molecules and lead optimization

Experienced in planning and execution of total synthesis of biologically active
molecules with moderate complexity

One of the molecules is currently in human clinical trials.

  

Education










Indian Institute of ScienceIndian Institute of Science











University of Hyderabad

PhD, Chemistry, 
Ph.D., University of Hyderabad, 2000 (Advisor: Professor Goverdhan Mehta).

 
Prof. Goverdhan Mehta





  

Experience




Senior ScientistNational Chemical Laboratory

National Chemical Laboratory

– Present 

http://www.ncl-india.org/




Section HeadAdvinus Therapeutics- A TATA Enterprise

Advinus Therapeutics- A TATA Enterprise
(7 months)
Drug Discovery - Medicinal Chemistry





Group LeaderAdvinus Therapeutics- A TATA Enterprise

Advinus Therapeutics- A TATA Enterprise
(2 years 5 months)
Drug Discovery - Medicinal Chemistry



Research InvestigatorDr. Reddy's Laboratories

Dr. Reddy's Laboratories
(10 months)
Drug Discovery - Medicinal Chemistry




Principal ScientistDr. Reddy's Laboratories

Dr.Reddy's Laboratories Ltd.
(3 years 1 month)
Drug Discovery - Medicinal Chemistry







Postdoc researchUniversity of Kansas

University of Kansas (2 years)
Post-doctoral with Prof. Jeffrey Aubé
(Univ. of Kansas, USA)

 
Jeff Aubé



PostdocresearchUniversity of Chicago

University of Chicago
(1 year)
Post-doctoral with Profs. Sergey A. Kozmin
(University of Chicago,USA)
 Sergey A. Kozmin




Research areas

  • Total Synthesis
  • Medicinal Chemistry
Our group research interests are broadly in total synthesis of biologically active compounds and medicinal chemistry. Current projects include the total synthesis of bioactive natural products such as antiinflammatory agents, antibacterial agents, antimalarial compounds and anti-cancer agents. Targets are chosen for their interesting biological activity and moderate complexity, which drives our creative solutions to their synthesis. Our ability to achieve an efficient synthesis enables us to access sufficient quantities of target molecule for biological profiling and ready access to different analogs that may prove to be more selective and efficacious as a drug-like molecule. We have plans to divert our total synthesis projects into medicinal chemistry projects by simplifying the complex structures. In medicinal chemistry front, our main interest is to use "silicon-switch approach" to discover novel drugs or drug-like molecules with improved pharmacokintetic (PK) and pharmacodynamic (PD) properties.


s reddy ncl
DEC2014 NCL PUNE INDIA
DR ANTHONY WITH DR REDDY


Some pictures of his group


NCL, PUNE



D. Srinivasa Reddy of CSIR-National Chemical Laboratory Pune devised (J. Org. Chem. 201378, 8149. DOI: 10.1021/jo401033j) a cascade protocol of Diels-Alder cycloaddition of 8 to the diene 7 followed by intramolecular aldol condensation, to give the enone 9. Oxidative manipulation followed by methylenation completed the synthesis of the commercially important grapefruit flavor Nootkatone (10).
Abstract Image
A simple and efficient synthesis of functionalized cis-hydrindanes and cis-decalins was achieved using a sequential Diels–Alder/aldol approach in a highly diastereoselective manner. The scope of this method was tested with a variety of substrates and was successfully applied to the synthesis of two natural products in racemic form. The highlights of the present work provide ready access to 13 new cis-hydrindanes/cis-decalins, a protecting group-free total synthesis of an insect repellent Nootkatone, and the first synthesis of a Noreremophilane using the shortest sequence.
A simple and efficient synthesis of functionalized cis-hydrindanes and cis-decalins was achieved using a sequential Diels–Alder/aldol approach in a highly diastereoselective manner. The scope of this method was tested with a variety of substrates and was successfully applied to the synthesis of two natural products in racemic form. The highlights of the present work provide ready access to 13 new cis-hydrindanes/cis-decalins, a protecting group-free total synthesis of an insect repellent Nootkatone, and the first synthesis of a Noreremophilane using the shortest sequence.
(4R*,4aS*,6R*)-4,4a-Dimethyl-6-(prop-1-en-2-yl)-4,4a,5,6,7,8-hexahydronaph thaen-2(3H)-one ((±)-Nootkatone 20)
(±)-Nootkatone 20 (19 mg, 65%). IRÏ…max(film) 2923, 1668, 1606, 1459 cm–1; 1H NMR (400 MHz, CDCl3) δ 5.77 (s, 1 H), 4.74 (s, 1 H), 4.72(s, 1 H), 2.50 (ddt, J = 15.3, 5.0, 1.8 Hz, 1 H), 2.40–2.24 (m, 4 H), 2.04–1.89 (m, 3 H),1.74 (s, 3 H), 1.40–1.29 (m, 2 H), 1.11 (s, 3 H), 0.96 (d, J = 6.7 Hz, 3 H); 13C NMR (100 MHz, CDCl3) δ 199.9, 170.7, 149.3, 124.8, 109.4, 44.0, 42.2, 40.6, 40.5, 39.5, 33.2, 31.7, 21.0, 17.0, 15.0.
 

Contact



Recent publications
Org. Lett.2013, 16, ASAP article
J. Org. Chem. 2013, 78, 8149
J. Org. Chem. 2013, 78, 6281
Org. Lett. 2013, 15, 1894
Chem. Commun.2013, 49, 3242
Org. Lett.2012, 14, 6222
Org. Biomol. Chem.2012, 10, 5385
J. Diabetes Metab.2013, ASAP article
Tetrahedron Lett.,2012, 53, 6343
RSC. Adv.2012, 2, 3596
Org. Lett.2011, 13, 3690
Tetrahedron Lett.2011, 33, 4313
Bioorg. Med. Chem. Lett.2011, 21, 4913
J. Org. Chem.2011, 76, 963
Org. Biomol. Chem.2011, 9, 744

Patents:
WO2013/054275 A1
WO2013/054366 A1
US8163704B2/2012
WO 2011/048148A2
US 2011/0171159A1
US 2011/0269700A1
US 2011/0230403A



///////////////

UPDATE


New route for Expensive drug Ivacaftor synthesis from CSIR-NCL, Pune, India

Cover image for Vol. 2015 Issue 32

Ivacaftor.svg
IVACAFTOR

Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carb­oxylic Acid Amides and the Expensive Drug Ivacaftor
N. VasudevanGorakhnath R. Jachak and D. Srinivasa Reddy*

Article first published online: 3 NOV 2015
DOI: 10.1002/ejoc.201501048







Abstract
A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop–Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.


REFERENCES

N. Vasudevan, Gorakhnath R. Jachak And D. Srinivasa Reddy, Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carb­oxylic Acid Amides and the Expensive Drug Ivacaftor, Eur. J. Org. Chem., , 0000 (2015), DOI:10.1002/ejoc.201501048.
http://academic.ncl.res.in/publications/index/select-faculty/2015/ocd

Breaking and Making of Rings: A Method for the Preparation …

onlinelibrary.wiley.com › … › Early View
6 days ago – European Journal of Organic Chemistry … 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive …

European Journal of Organic Chemistry – Wiley Online Library

onlinelibrary.wiley.com › … › European Journal of Organic Chemistry
European Journal of Organic Chemistry ….. examples and is successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.

Breaking and making – Wiley Online Library

onlinelibrary.wiley.com › … › Early View › Abstract
6 days ago – … for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug IvacaftorEuropean Journal of Organic Chemistry.


Update dec2015

DR SRINIVASA REDDY gets NASI – Reliance Industries Platinum Jubilee Award (2015) for Application Oriented Innovations in Physical Sciences.


DR REDDY
DR SRINIVASA REDDY  recieving NASI - Reliance Industries Platinum Jubilee Award (2015) for Application Oriented Innovations in Physical Sciences.
Dr. D. Srinivasa Reddy, Senior Scientist, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune – 411 008

AWARD CLICK HERE....LINK

PUNE: Senior scientist of National Chemical Laboratory (NCL), D Srinivasa Reddy has been selected for this year's NASI-Reliance Industries Platinum Jubilee award for the application oriented innovations in the area of physical sciences instituted by the National Academy of Sciences, India (NASI). Two awards each in physical sciences and two in biological sciences are given every year, a statement issued by NCL said.
Manindra Agrawal from Department of Computer Science and Engineering, Indian Institute of Kanpur is the other recipient of this award in physical sciences. Each award carries a plaque and Rs 2 lakh cash.
The award will be presented in the 85th annual session of National Academy of Sciences, India. Reddy's research group interests are in the field of total synthesis and drug discovery by applying medicinal chemistry. He has also been involved in the synthesis of the agrochemicals like small molecules for crop protection, said the statement. The total synthesis of more than 20 natural products has been achieved in his lab including a sex pheromone that attracts the mealy bugs and has potential use in the crop protection.
On the medicinal chemistry front significant progress has been made by his group using a new concept called silicon-switch approach towards central nervous system drugs. Identification of new chemical entities for the potential treatment of diabetes and infectious diseases is being done in collaboration with industry partners.



Some details
The National Academy of Sciences, India (NASI) 5, Lajpatrai Road, Allahabad – 211002 NASI-RELIANCE INDUSTRIES PLATINUM JUBILEE AWARDS FOR THE YEAR 2015 FOR APPLICATION ORIENTED INNOVATIONS COVERING BOTH PHYSICAL AND BIOLOGICAL SCIENCES NASI invites nominations for the NASI-Reliance Industries Platinum Jubilee Awards for APPLICATION ORIENTED INNOVATIONS for the year 2015. The nominee should be an Indian citizen / Overseas Citizen of India working in India and below the age of 50 years as on April 15, 2015. Areas for the Awards – Physical Sciences, including – Chemistry, Engineering, Mathematics, Physics, Electronics, Nanotechnology, Information & Computer Sciences, Earth and Atmospheric Sciences; Biological Sciences, including – Agriculture, Animal and Plant Sciences, Environment, Biotechnology, Biochemistry, Bioprocess Engineering, Bioinformatics, all branches of medical sciences and Nanotechnology. Number and Value of Awards – two in Physical Sciences and two in Biological Sciences each year. Each award carries a Plaque and Rs. 2 lakhs in cash. Nominators and Last Date – All Science Secretaries, Secretary HRD, Director Generals – CSIR, ICMR & ICAR; Directors of IITs, IIITs, National Laboratories, Industries with well recognized R&D units including private research institutions; Vice-Chancellors of all Universities – Central & State; Directors of Indian Institute of Science, Bangalore, AIIMS, New Delhi, PGI’s of Medical Research, Chairman, UGC; Presidents of all Science and Engineering Academies (Engineering, Medical, Agriculture); All Fellows of the NASI. The nomination shall be made in the prescribed format. Twenty (20) copies of the nomination form along with only one soft copy (in CD), complete in all respect with the supporting documents, must reach the Academy latest by April 15, 2015. A candidate may only be nominated once. However, a nomination will remain valid for consideration for 3 years or the age eligibility which ever expires earlier. Selection of the Awardees – As per Regulations of NASI Presentation of the Awards – The presentation of the Awards will be made at the time of 85 th Annual Session of NASI. Details and Nomination form for the award are also available on NASI’s website http://www.nasi.org.in and http://www.nasi.nic.in ................http://www.nasi.org.in/NASI-Reliance%20Industries%20Platinum%20Jubilee%20Awards%202015.pdf
SEE
http://www.nasi.org.in/NASI-Reliance%20Industries%20Platinum%20Jubilee%20Awardees%20(2015).htm
PUNE: Senior scientist at National Chemical Laboratory (NCL) D Srinivasa Reddy has bagged yet another award, the NASI-Reliance Industries Platinum Jubilee award for the year 2015.
This is the second award Reddy has won in a span of less than a fortnight. Earlier, he was selected for the bronze medal presented by the Chemical Research Society of India (CRSI). He has also been a recipient of excellence award from the National Drug Research Institute.
The platinum jubilee award is being conferred for his work in application-oriented innovations in physical sciences category.
Every year, this award recognises two scientists, each working in the fields of physical and biological sciences.
The other scientist who has been awarded in this category is Manindra Agarwal from IIT, Kanpur.
Reddy along with his team has been involved in several high-end research in drug discovery, mainly by applying medicinal chemistry. Other major works he undertook also involve synthesising of agrochemicals meant to be used for crop protection.
He also has vast experience working with various pharmaceutical companies prior to joining NCL in 2010.
The award consists of cash of Rs 2 lakh.

NASI
National Academy of Sciences, India (www.nasi.org.in) was founded in 1930 with the objective to provide a national forum for the scientists to help them publish their research work and discuss the issues for the solutions. NASI-Reliance together give two awards each in the areas of physical and biological sciences for the application oriented innovations started from the year 2006. Areas for the Awards – Physical Sciences, including Chemistry, Engineering, Mathematics, Physics, Electronics, Nanotechnology, Information & Computer Sciences, Earth and Atmospheric Sciences; Biological Sciences, including Agriculture, Animal and Plant Sciences, Environment, Biotechnology, Biochemistry, Bioprocess Engineering, Bioinformatics, all branches of medical sciences and Nanotechnology.


UPDATE.........

Exciting lecture by Dr Srinivasa Reddy at Glenmark research centre, Mahape, Navi mumbai, India, 1 Feb 2016






Exciting lecture by Dr Srinivasa Reddy of NCL pune India, on his achievements in Drug discovery at Glenmark research centre, mahape, Navi mumbai, India, 1 Feb 2016, He is Prestigious recipient of Shanti swaroop Bhatnagar award 2015


WITH Abraham Thomas



Abraham Thomas,  
ME
AND
DR GHARAT




//////////DR SRINIVASA REDDY , NASI - Reliance Industries Platinum Jubilee Award, 2015, Application Oriented Innovations in Physical Sciences,