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Wednesday, 25 February 2015

Dr. Srivari Chandrasekhar


Chief Scientist & Head, Division of Natural Products Chemistry, CSIR- Indian Institute of Chemical Technology
Chandrasekhar obtained his Bachelor’s and Master’s degrees in 1982 and 1985 respectively, from Osmania University, Hyderabad and excelled in the same with distinction. He then joined A. V. Rama Rao’s group at CSIR–IICT and earned his doctorate in 1991, also from Osmania University. Between 1991 and 1994 he was associated with J. R. Falck (University of Texas Southwestern Medical Center) as a postdoctoral student. In 1994, Chandrasekhar joined his parent institute (CSIR–IICT) as a scientist

Director 
CSIR-Indian Institute of Chemical Technology                              
(Council of Scientific and Industrial Research)
Ministry of Science & Technology, Government of India
Tarnaka, Hyderabad-500007, Telangana, INDIA 



Landline27193030
Mobile+919440802787
Fax
Email IDdirector@iict.res.in

Council of Scientific and Industrial Research
Ministry of Science and Technology, Government of India

CSIR-IICT
CSIR-Indian Institute of Chemical Technology






http://www.iictindia.org



ICOS21 at IIT-Bombay ..Mumbai, India,. An International conference on Organic chemistry....Day one...11 dec 2016, A chance to meet, DR SRIVARI CHANDRASEKHAR, Director IICT Hyderabad





Chandrasekhar obtained his Bachelor’s and Master’s degrees in 1982 and 1985 respectively, from Osmania University, Hyderabad

After obtaining a Ph.D. under the supervision of Dr. A. V. Ramarao at the Indian Institute of Chemical Technology, Hyderabad,
DR AV RAMA RAO


He moved to theUniversity of Texas Southwestern Medical School for post-doctoral research with Professor J. R. Falck
Professor J. R. Falck

and
then to the University of Goettingen, Germany as Alexander von Humboldt Fellow in the group of Professor L. F. Tietze.
 Professor L. F. Tietze

His research interests include the synthesis of marine natural products, peptides and peptidomimetics, combinatorial chemistry and new solvent media for organic synthesis.
He is a recipient of a Young Scientist award of the Indian National Science Academy, B M Birla Science Prize and National Academy of Sciences-Reliance Industries Platinum Jubilee Award. He has over 190 publications, 2 patents, and guided 20 students for their Ph.D. degrees.


According to a press release here on Tuesday, Dr. Chandrasekhar has been conferred the honour for his significant contribution in organic chemistry and medicinal chemistry.
The major contributions include synthesis of complex natural products, especially of marine origin with anti-cancer and anti-depressant properties, green chemistry and automation chemistry to make large number of new chemicals.
He has produced 25 Ph.D. students and published more than 200 papers in international journals. He is also a fellow of National Academy of Sciences.
Image result for srivari chandrasekhar
India has achieved many prizes in 2014. Before the year ends IICT scientist Srivari Chandrasekhar has added one more prize, he wins Infosys Prize. The scientist who has made important contributions in potential drug developments. Srivari Chandrasekhar from CSIR-IICT , Hyderabad, was announced the winner of the Infosys Prize 2014 in Physical Sciences. The award includes a purse of Rs. 55 lakh, a 22 carat gold medal and citation. The award will be presented by The President on January 5 in Kolkata. The prize is awarded annually by the Infosys Foundation.
He had won the CSIR Technology award-2014 along with his team member
Chandrasekhar’s current contribution is to develop a technology for manufacturing Misoprostal, an abortive drug also used in the treatment of ulcers. Now we can easily get rid of Ulcer.
He has successfully prepared some important drug molecules such as bedaquiline for multi-drug resistant TB, Galantamine for Alzheimer’s disease, Sertraline for treatment of depression, Nebivolol for hypertension and marine natural products such as Eribulin, Azumamide, Arenamide and Bengazole which are scarce to get from nature, with potent biological activities.
As he moves on achieving his target , he has made contributions in synthesizing complex and scarcely available natural products in the laboratory using easily available chemicals.
Chandrasekhar has over 250 publications in national and international journals to his credit.
Prof. Chandrasekhar has displayed an exceptional flair for identifying and synthesizing molecules of biological relevance, topical synthetic interest and utility to industry. His research efforts, with an impressive degree of innovations and enterprise, have led to the synthesis of complex and scarcely available natural products and new molecular entities for affordable healthcare. His endeavors have provided cost-effective technologies to chemical industry through identification of new reagents / solvents for specific transformations. Chandrasekhar's group has synthesized several classes of complex natural products in optically pure form employing chiral pool precursors and catalytic asymmetric reactions and his syntheses of pladienolide, azumamide, bengazole etc., bear testimony to the efficacy of such approaches.

His passion and commitment to topical health related problems is through provisioning for better and affordable access to important drugs. Mention may be made of hissynthesis of bedaquiline, the first drug approved by FDA after a gap of over 40 years for the treatment of multi-drug resistant TB through simpler transformations and higher yields to ensure ready availability. He along with a team atIICT has developed a scalable synthetic route for misoprostol (a hormone like biologically important synthetic prostaglandin) used to prevent gastric ulcer, induce labor and / or abortion (particularly for safe termination of unwanted pregnancies), which has already been commercialized.
More prudent research field has been the identification of novel peptido-mimetics wherein research group of Dr. S. Chandrasekhar has synthesized β-sugar amino acids, norbornene-based, aminoxy acids of furanoses and nucleoside-based amino acids and demonstrated that these monomers in various combinations of oligomerization resulted in predefined secondary structures including nanotubes.
Dr S. Chandrasekhar has for the first time identified polyethylene glycol (PEG) as a recyclable solvent for organo-metallic reactions wherein both the solvent and catalyst can be recycled. This unprecedented report triggered various research programs using PEG as a solvent in different parts of the world. Some of the reactions worth mentioning using PEG as solvent are as follows: Heck reaction in PEG, Sharpless asymmetric dihydroxylation (was performed for the first time in PEG), PtO2 recycle and H2 absorption studies. This work has found direct applications in developing non-infringing technologies for APIs.
Dr S Chandrasekhar has never hesitated to take-up challenging process development subjects relevant to health care. The processes developed for semi-synthesis of Taxol (M/s. Cipla), Misoprostol (M/s. AVRA) and Carboprost (M/s. AVRA) are worth mentioning and biotech problems are also addressed by him as evident in the synthesis of Fondaparinux as anti-coagulant agent (Table 1). In addition, as part of the ‘Drug Discovery Process,’ over 500 new chemical entities are being synthesized in his group. The process developed for EV-077 sponsored by M/s. Evolva biotech helped them to enter into phase I clinical studies.

Several combinatorial libraries were prepared in his group as new chemical entities for screening against cancer (US patent 7179937), TNFα, 5HT antagonism etc. Two review articles written by him on hybrid natural products (Angewandte Chemie 2003, 3996) and prostaglandins (Chemical Review, 2007, 3286) are worth mentioning. A recent contribution of Dr. S. Chandrasekhar is the synthesis of bedaquiline (2S)-R207910, a novel anti-tuberculosis molecule, which has appeared as cover page with theme “Chemistry for a healthy world” in Eur. J. Org. Chem. 2011, 2057.

Education
Alexander von Humboldt Fellow in Organic Chemistry during 2001 from University of Goettingen, Germany;
Post Doctoral studies in Organic Chemistry during 1991-1994 from UT Southwestern Medical Center, Dallas, TX
Ph.D in Organic Chemistry during 1991 from Osmania University
(work done at IICT, Title:Synthesis of Some Biologically Active Compounds; Supervisor: Dr. A. V. Rama Rao, D. Sc., FNA, FTWAS)
M.Sc in Organic Chemistry during 1985 from Osmania University
B.Sc in Botany, Zoology, Chemistry during 1982 Osmania University

Employment
Junior Research Fellow from 1986 to 1988 at Indian Institute of Chemical Technology, Hyderabad;
Senior Research Fellow from 1988 to 1991 at Indian Institute of Chemical Technology, Hyderabad;
Post Doctoral Fellow from 1991 to 1994 at University of Texas, South western Medical Center, Dallas, USA;
Scientist C from 1994 to 1999 at Indian Institute of Chemical Technology, Hyderabad;
Scientist EI from 1999 to 2004 at Indian Institute of Chemical Technology, Hyderabad;
Alexander von Humboldt Fellow from 2000 to 2001 at University of Goettingen, Germany;
Scientist EII from 2004 to 2005 at Indian Institute of Chemical Technology, Hyderabad;
Scientist F from 2005 to 2010 at Indian Institute of Chemical Technology, Hyderabad;
Scientist G, Chief Scientist from 2010 to 2015 at Indian Institute of Chemical Technology, Hyderabad;
Director, from June 2015 at Indian Institute of Chemical Technology, Hyderabad;


PATENTS

  1. International patent, Gurjar, Mukund K.; (Pune, IN) ; Wakharkar, Radhika D.; (Pune, IN) ; Desiraju, Gautam R.; (Hyderabad, IN) ; Nangia, Ashwini; (Hyderabad, IN) ; Yadav, J. S.; (Hyderabad, IN) ; Burman, Anand C.; (Ghaziabad, IN) ; Mukherjee, Rama; (Ghaziabad, IN) ; Borate, Hanumant Bapurao; (Pune, IN) ; Chandrasekhar, Srivari; (Hyderabad, IN) ; Jaggi, Manu; (Ghaziabad, IN) ; Singh, Anuo T.; (Ghaziabad, IN) ; Kapoor, Kamal K.; (Ghaziabad, IN) ; Sarkhel, Sanjay; (Hyderabad, IN) ; Sairam, Kalapatapu V.V.M.; (Hyderabad, IN) US 7179937. Cyclopentenone derivatives for cancer therapy.
  2. Saibal Das, Rene Gree, J. S. Yadav, S. Chandrasekhar, P Srihari and A.V. Rama Rao. (Application no:1530/CHE/2007, Filing date: 16.07.07, Indian patent filed). Process for enzymatic resolution of racemic monosubstituted cis-2-cycloalkene-1,4-diols in ionic liquids.
  3. S.Chandrasekhar, T. Pavan Kumar, Vidyavathi Patro and Ch. Rajireddy. (Patent submitted to IICT IPM Division). Novel triazoles andoxime ethers from hydroxylamine derivatives.


PUBS
  1. Enantioselective synthesis of Pladienolide B and truncated analogues as new anti-cancer agents V Praveen Kumar and S. Chandrasekhar* Organic Letters 2013, 15, 3610-3613
  2. Formal Synthesis of Anti-Platelet Drug, Beraprost N. Kesava Reddy, B. V. D. Vijaykumar and S. Chandrasekhar* Organic Letters 2012, 14, 299-301
  3. Total Synthesis of Bengazole A S. Chandrasekhar,* and A. Sudhakar Organic Letters 2010, 12, 236-238
  4. Polyethylene glycol (400) as superior solvent medium against ionic liquids for catalytic hydrogenations with PtO2 S. Chandrasekhar,* S. Jaya Prakash and Ch. Lohitha Rao J. Org. Chem. 2006, 71, 2196-2199
  5. Expanding the Conformational Pool of cis-β-Sugar Amino Acid: Accommodation of β-hGly Motif in Robust 14-Helix S. Chandrasekhar,* M. Srinivasa Reddy, B. Nagendra Babu, B. Jagadeesh, A. Prabhakar and B. Jagannadh. J. Am. Chem. Soc. 2005, 127, 9664-9665

Srivari Chandrasekhar

Srivari ChandrasekharPhysical Sciences, 2014
Affordable drugs using clean green methods
Affordable drugs using clean green methods
View Infographic
Srivari Chandrashekar
Chief Scientist and Head, Division of Natural Products Chemistry, CSIR‑Indian Institute of Chemical Technology, Hyderabad, India
The Infosys Prize 2014 in Physical Sciences is awarded to Dr. S. Chandrasekhar for his diverse and notable contributions in synthetic organic chemistry with special focus on the synthesis of complex molecules from natural sources. He has devised innovative, practical approaches to pharmaceuticals of current interest to industry.

Congratulatory Message From The Jury Chair – Shrinivas Kulkarni

Congratulations Srivari for winning the 2014 Prize in Physical Sciences. Your work was impressive not only in the breadth of chemistry it covered but also for its impact on society. In fact your approach of concept to commercialization or ‘bench to bed’ is truly unique for academic scientists in the Indian context. Not only has your work had important ramifications in chemistry but it will affect branches of society such as drugs and pharmaceuticals; agro chemicals and materials. Congratulations again.

Bio

Dr. Srivari Chandrasekhar is Chief Scientist and Head, Division of Natural Products Chemistry at the Indian Institute of Chemical Technology (IICT). He received his B.Sc. (1982), M.Sc. (1985) and Ph.D. (1991) degrees from Osmania University, and pursued post-doctoral research at the UT Southwestern Medical Center, Dallas, USA, with Prof. J. R. Falck. As a Humboldt Fellow at the University of Göttingen, he worked on the synthesis of hybrid natural products with Prof. L. F. Tietze.
Chandrasekhar was instrumental in setting up the state-of-the-art Molbank facility at the IICT for the storage and retrieval of chemical samples for HT screening.
He has over 240 publications in national and international journals. He has mentored a large number of doctoral and post-doctoral students and won several awards, including the INSA medal for Young Scientists, CSIR Young Scientist Award, AVRA Young Scientist Award, and the FAPCCI award.
He and his team won the CSIR Technology Award, 2014 for commercializing the process for misoprostol. He is a Fellow of the Indian Academy of Sciences, Bangalore, the National Academy of Sciences, Allahabad, and the Indian National Science Academy, New Delhi.

Scope And Impact Of Work

Dr. S. Chandrasekhar has displayed a flair for identifying and synthesizing molecules of biological relevance, topical synthetic interest and utility to industry. His research efforts, with an impressive degree of innovation and enterprise, have led to the synthesis of complex and scarcely available natural products and new molecular entities for affordable healthcare. His endeavors have provided cost-effective technologies to the chemical industry through the identification of new reagents / solvents for specific transformations.
Chandrasekhar's group has synthesized several classes of complex natural products in optically pure form employing chiral pool precursors and catalytic asymmetric reactions and his syntheses of pladienolide, azumamide and bengazole bear testimony to the efficacy of such approaches.
His passion and commitment to topical health-related problems is evident in his provisioning for better and affordable access to important drugs. This includes his synthesis of bedaquiline, the first drug approved by FDA in over 40 years for the treatment of multidrug-resistant TB. His team at IICT has developed a scalable synthetic route for misoprostol (a hormone-like biologically important synthetic prostaglandin), used to prevent gastric ulcer, induce labor and / or safely terminate unwanted pregnancies, and this has already been commercialized.
Chandrasekhar has developed methodologies and reagents which help in achieving the synthesis of structurally complex bio-actives in lesser number of steps and avoid the use of hazardous solvents. His contribution in this area has been the promotion of PEG (polyethyleneglycol) as an eco-friendly solvent for processing and recycling expensive metal catalysts based on Palladium, Osmium and Ruthenium in diverse reactions. This work has inspired researchers worldwide to use PEG.
Chandrasekhar has mentored many doctoral and post-doctoral students and is recognized as an inspirational leader among the young generation. His research has drawn the attention of pharma and chemical companies in India and helped enhance their competitiveness.

Citation By The Jury

Dr. Chandrasekhar's group has synthesized over 30 complex natural products and developed several processes to provide better and affordable access to important drugs. Among these is bedaquiline, the first drug approved by FDA in over 40 years for the treatment of multidrug-resistant TB, which Dr. Chandrasekhar has synthesized through simpler transformations and higher yields to make it affordable and accessible.
He, along with his team, has developed a scalable synthetic route for misoprostol (a hormone similar to biologically important synthetic prostaglandin). This is used to prevent gastric ulcer, induce labor and / or safely terminate unwanted pregnancies. This has already been commercialized.

HDr. Chandrasekhar has mentored a large number of doctoral and post-doctoral students and is recognized as an inspirational leader among the young generation. His research has drawn the attention of pharma and chemical companies in India and helped many of them enhance their competitiveness.

Paper

Total synthesis of a thromboxane receptor antagonist, terutroban

Org. Biomol. Chem., 2015, 13,2951-2957
DOI: 10.1039/C4OB02302A, Paper

*Corresponding authors
aDivision of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India 500 007
E-mail: srivaric@iict.res.in;
Fax: +91-40-27160152 ;
Tel: +91-40-27193210, 27193434
bAcademy of Scientific and Innovative Research, New Delhi, India
Org. Biomol. Chem., 2015,13, 2951-2957
DOI: 10.1039/C4OB02302A


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1 comment:

  1. Indeed Great ... Career graph clearly shows his committment towards country and not tobe as NRI ... Way to go Sir big salute ..

    ReplyDelete