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Friday 23 October 2015

Parven Luthra



Dr. Parven Luthra

Teva API as Head R&D India

links

https://in.linkedin.com/pub/dr-parven-luthra/15/224/1a
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parvenluthra@gmail.com
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Parven Luthra 

Experience

NOW
Teva API as Head R&D India








Vice president API R&D

Actavis Pharma ( Watson Pharma pvt ltd.)
– Present (3 years 8 months)Ambernath, Mumbai
I am heading group of about 85 scientist working in the areas of process development, analytical development and technology transfer.








Head-API development

Sandoz Pvt. Ltd.
(1 year 10 months)
I was responsible for all research and development activities for developing processes for new APIs.






Vice president

Parabolic drugs Ltd.
(3 years 5 months)
Heading a group of about 80 scientists working in the areas of Chemical research , analytical research, Intellectual property management and regulatory affairs. The major goal is to develop cost efficient, non infringing process for various therapeutic segments. Also responsible for the contract research and CRAMS activities also.




Associate vice president ( Chemical research development and IPR)

Alembic Ltd.
(1 year 7 months)
Heading the API research and development acitivites and head of IPR department at BIOARC , Alembic ltd.






Asst. General Manager

orchid chemicals and pharmaceuticals ltd.
(5 years 6 months)
Working as head of R&D for developing process for APIs







research scientist

Ranbaxy
(2 years 4 months)





research associates

J.K. Drugs and pharmaceuticals ltd
(5 months)





Education





NALSAR university

Post graduate diploma in patent law




Delhi University


MSc. , Ph.D, Organic chemistry



Delhi University


M.Sc., chemistry




Delhi University


BSc, chemistry







Patents by Inventor Parven Kumar Luthra

Application number: 20150038727
Abstract: The present invention relates to a process for preparing silodosin with high optical purity up to 99.9% enantiomeric excess (e.e.) or above. The process makes use of a method step, in which the enantiomers contained in a racemic mixture of a compound represented by the general formula V: wherein * denotes the asymmetric center, R1 is a protecting group, and R2 is cyano or carbamoyl, are separated.
Type: Application
Filed: October 19, 2012
Issued: February 5, 2015
Assignee: SANDOZ AG
Inventors: Parven Kumar Luthra, Sachin Bhuta, Chandrakant Pise Abhinay, N. Chavan Dattatraya, D. Metkar Shashikant
 https://www.google.co.in/patents/WO2013056842A1
 The molecular structure of silodosin (XXV) is shown below.
(XXV)


Scheme 5. Conversion of com ound V to silodosin




Example 15. Silodosin (XXV)
10.0 g of crude silodosin (optical purity = 92.0% e.e.) was dissolved in isopropyl acetate (160 ml) at 55°C. The resulting clear solution was gradually cooled to 25°C under stirring. The suspension was further cooled to 15°C and stirred for 2 hours. The precipitated solid was filtered and dried at 50°C under vacuum to obtain 8.2 g of XXV with an optical purity of 98.0% e.e. Example 16. Silodosin (XXV)
10.0 g of crude silodosin (optical purity = 98.0% e.e.) was dissolved in isopropyl acetate (160 ml) at 55°C. The resulting clear solution was gradually cooled to 25°C under stirring. The suspension was further cooled to 15°C and stirred for 2 hours. The precipitated solid was filtered and dried at 50°C under vacuum to obtain 8.0 g of XXV with an optical purity of 99.5% e.e.

Patent number: 8471039
Abstract: Processes for the preparation of Silodosin and its intermediates comprising reductive amination of compound of Formula (VIII) with a compound of Formula (VII) or a compound of Formula (XV) in a suitable solvent using a reducing agent.
Type: Grant
Filed: September 13, 2010
Issued: June 25, 2013
Assignee: Sandoz AG
Inventors: Shreerang Joshi, Sachin Bhuta, Sanjay Talukdar, Sudhir Sawant, Deepak Venkataraman, Abhinay Pise, Shashikant Metkar, Dattatraya Chavan, Parven Kumar Luthra

Application number: 20120165548
Abstract: Processes for the preparation of Silodosin and its intermediates comprising reductive amination of compound of Formula (VIII) with a compound of Formula (VII) or a compound of Formula (XV) in a suitable solvent using a reducing agent.
Type: Application
Filed: September 13, 2010
Issued: June 28, 2012
Assignee: SANDOZ AG
Inventors: Shreerang Joshi, Sachin Bhuta, Sanjay Talukdar, Sudhir Sawant, Deepak Venkataraman, Abhinay Pise, Shashikant Metkar, Dattatraya Chavan, Parven Kumar Luthra 
Patent number: US 7968731
Abstract: An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
Type: Grant
Filed: March 21, 2007
Issued: June 28, 2011
Assignee: Alembic Limited
Inventors: Pandurang Balwant Deshpande, Ashok Prataprai Shanishchara, Trushar Rajanikant Shah, Hitarth Harshendu Acharya, Parven Kumar Luthra
 
The present invention relates to a process for the purification of Ropinirole hydrochloride of formula (Ia).



According to the present invention, there is provided an improved process for purification of Ropinirole hydrochloride of formula (Ia)

    • comprising steps of:
  • (i) dissolving Ropinirole hydrochloride in water;
  • (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal;
  • (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base;
  • (iv) treating the free base obtained in step (iii) with ethanolic HCl to give Ropinirole hydrochloride.


Patent number: 7863462
Abstract: The present invention provides an improved process for the purification of ropinirole hydrochloride. The process includes (i) treating ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating the ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
Type: Grant
Filed: March 21, 2007
Issued: January 4, 2011
Assignee: Alembic Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Hitarth Harshendu Acharya
Application number: 20100249433
Abstract: An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
Type: Application
Filed: March 21, 2007
Issued: September 30, 2010
Assignee: ALEMBIC LIMITED
Inventors: Pandurang Balwant Deshpande, Ashok Prataprai Shanishchara, Trushar Rajanikant Shah, Hitarth Harshendu Acharya, Parven Kumar Luthra 
Application number: 20100234632
Abstract: The present invention relates to an improved process for the preparation of Entacapone of formula (I) comprising a step of, condensation of 3,4-dihydroxy-5-nitrobenzaldehyde of formula (II) with N,N-diethylcyanoacetamide of formula (III) in the presence of two component solvent system, a catalyst and optionally a phase transfer catalyst to give Entacapone of formula (I).
Type: Application
Filed: August 13, 2007
Issued: September 16, 2010
Inventors: Pandurang Balwant Deshpande, Anand Kumar Randey, Dharmesh Ramniklal Dhameliya, Bhimsing Rathod Dayawant, Parven Kumar Luthra
Patent number: 7777039
Abstract: The present invention relates to an improved process for the preparation of 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-1,2,3,4-tetrahydroquinolin-2-one (Aripiprazole) having dimer impurity less than 0.15%, particularly, the present invention relates to an improved process for the preparation of 7-(4-chlorobutoxy)-3,4-dihydrocarbostyril of formula (I) having dimer impurity less than 0.5% which includes a step of reacting 7-hydroxy-tetrahydroquinolinone of formula (III) with 1-bromo-4-chlorobutane in the presence of a base in a solvent.
Type: Grant
Filed: June 7, 2006
Issued: August 17, 2010
Assignee: Alembic Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Ashok Prataprai Shanishchara, Ramesh Manepalli, Dharmesh Balvantrai Mistry
Application number: 20100179332
Abstract: The present invention provides an improved process for the purification of ropinirole hydrochloride. The process includes (i) treating ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating the ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
Type: Application
Filed: March 21, 2007
Issued: July 15, 2010
Assignee: Alembic Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Hitarth Harshendu Acharya
Patent number: 7741477
Abstract: The present invention relates to a process for the purification of Sucralose of formula (I) which comprises acetylation of substantially impure Sucralose to its penultimate intermediate 4,1?,6?-trichloro-4,1?,6?-trideoxy galactosucrose penta-acetate (TOPSA) of formula (VI) followed by purification of TOPSA and then deacetylation of purified TOPSA.
Type: Grant
Filed: January 10, 2007
Issued: June 22, 2010
Assignee: Alembic Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Sanjiv Onkarsingh Tomer, Piyush Maheshbhai Rana, Jigar Kamleshbhai Patel
Application number: 20100113798
Abstract: A process for the preparation of Irbesartan of formula (I) using the step of, reacting biphenyl derivative of formula (VIa) wherein R represents a group selected from —CONH2 or compound of formula wherein X represents H or C1-4 alkyl, preferably methyl; or any other such group which can be converted to cyano group, with 1-veleramido cyclopentane carboxylic acid of formula (V) in the presence of an acid in an organic solvent to give biphenyl derivative of formula (VIIa) wherein R has the same meaning as mentioned hereinabove.
Type: Application
Filed: January 7, 2010
Issued: May 6, 2010
Assignee: ALEMBIC LIMITED
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Dhiraj Mohansinh Rathod, Hitesh Kantilal Patel, Pinky Tarak Parikh
Patent number: 7683205
Abstract: The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1=R2=H or R1=H and R2=CH3 or an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).
Type: Grant
Filed: October 31, 2006
Issued: March 23, 2010
Assignee: Alembic Limited
Inventors: Pandurang Balwant Deshpande, Kishore Khemani, Bharat Becharbhai Boda, Tushar Rajnikant Shah, Hitarth Harshendu Acharya, Parven Kumar Luthra
Patent number: 7652147
Abstract: A process for the preparation of Irbesartan of formula (I) using the steps of: (i) reacting 4? aminomethyl-2-cyano biphenyl of formula (VI) with 1-veleramido cyclopentane carboxylic acid of formula (V) in an organic solvent and in the presence of an acid, without activating the —COOH group of compound of formula (V) to give 1-(2?cyanobiphenyl-4-yl-methylaminocarbonyl)-1-pentanoylamino cyclopentane of formula (VII). converting the compound of formula (VII) obtained in step (i) to Irbesartan of formula (I) by reacting the compound of the formula (VII) with tributyl tin azide in o-xylene to give Irbesartan of formula (I).
Type: Grant
Filed: April 19, 2006
Issued: January 26, 2010
Assignee: Alembic Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Dhiraj Mohansinh Rathod, Hitesh Kantilal Patel, Pinky Tarak Parikh
Application number: 20090312538
Abstract: The present invention relates to an improved process for the preparation of Sucralose having purity of at least 99.6% comprising steps of (i) dissolving substantially impure Sucralose in water (ii) treating the solution obtained in step (i) with a partially water immiscible solvent (iii) washing the said solvent phase obtained in step (ii) with an amount of water sufficient to remove polar impurities (iv) crystallizing the product from partially water immiscible solvent (v) recrystallizing the solid obtained in step (iv) from water.
Type: Application
Filed: October 19, 2006
Issued: December 17, 2009
Assignee: Alembic Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Sanjiv Onkarsingh Tomer, Kashyap Ravindrabhai Wadekar, Piyush Maheshbhai Rana, Kamlesh Shankarlal Kanzariya
Patent number: 7439385
Abstract: The present invention provides a novel process for preparation of bisphosphonic acid derivatives or pharmaceutical acceptable salt thereof, by reacting carboxylic acid having structural formula (II) with phosphorous acid and a halophosphorous compound, wherein halophosphorous compound is selected from the group comprising of PCl3, PCl5, POCl3, PBr3, POBr3, and PBr5 in presence of diphenyl ether.
Type: Grant
Filed: July 24, 2006
Issued: October 21, 2008
Assignee: Alembic Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra
Application number: 20080051352
Abstract: The present invention relates to the process for the preparation of compounds of formula (I) or its pharmaceutically acceptable salts wherein, R is
Type: Application
Filed: December 18, 2006
Issued: February 28, 2008
Assignee: ALEMBIC LIMITED
Inventors: Pandurang Balwant Deshpande, Manish Kanchanbhai Patel, Kalpesh Haribhai Dhameliya, Parven Kumar Luthra
Application number: 20080045743
Abstract: The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1=R2=H or R1=H and R2=CH3 or an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).
Type: Application
Filed: October 31, 2006
Issued: February 21, 2008
Assignee: ALEMBIC LIMITED
Inventors: Pandurang Balwant Deshpande, Kishore Khemani, Bharat Becharbhai Boda, Tushar Rajnikant Shah, Hitarth Harshendu Acharya, Parven Kumar Luthra
Patent number: 6919449
Abstract: The present invention relates to a method for the preparation of cephalosporin antibiotic of the formula (II), which comprises hydrolyzing and halogenating the ester of formula (III) by photochemical irradiation in one pot using a halogenating agent in the absence or presence of a solvent, to produce compound of formula (I), activating the 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) using conventional activation agents gives compound of formula (IV), condensing the activated compound of the formula (IV) with 7-amino cephem derivative of the formula (V) to produce a compound of formula (VI), and cyclizing the compound of formula (VI) with thiourea to give cephalosporin compounds of the formula (II).
Type: Grant
Filed: September 18, 2002
Issued: July 19, 2005
Assignee: Orchid Chemicals and Pharmaceuticals Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Pratik Ramesh Sathe, Sivakumaran Sundaravadivelan, Praveen Nagesh Ganesh
Patent number: 6833459
Abstract: The present invention provides a process for the preparation of 4-methyl-5-formyl-thiazole of the formula (I) which comprises reducing the thiazole ester of the formula (III) to thiazole alcohol of the formula (IV), using sodium borohydride in the presence of AlCl3 in a solvent and oxidising using an oxidizing agent the thiazole alcohol of the formula (IV) to obtain 4-methyl-5-formyl-thiazole of the formula (I).
Type: Grant
Filed: December 5, 2002
Issued: December 21, 2004
Assignee: Orchid Chemicals & Pharmaceuticals Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Rajesh Vyas, Ramakrishna Kamma
Application number: 20040132995
Abstract: The present invention relates to a process for the preparation of cephalosporin antibiotics of the formula (I) 1
Type: Application
Filed: November 5, 2003
Issued: July 8, 2004
Assignee: ORCHID CHEMICALS & PHARMACEUTICALS, LTD.
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Ramakrishna Kamma, Gedi Sreedhar

Patent number: 6713625
Abstract: The present invention provides a process for the preparation of Cefditoren of the formula (I) which comprises acylating 7-amino-cephem carboxylic acids of the general formula (IV) where R3 is hydrogen or trimethylsilyl with thioester derivatives of the formula (II) wherein R1 represents C1-C4 alkyl or phenyl in an organic solvent in the presence of an organic base at a temperature in the range of −10° C. to 30° C.
Type: Grant
Filed: May 23, 2002
Issued: March 30, 2004
Assignee: Orchid Chemicals & Pharmaceuticals Ltd.
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra
Application number: 20030225265
Abstract: The present invention provides a process for the preparation of Cefditoren of formula (I) 1
Type: Application
Filed: May 23, 2002
Issued: December 4, 2003
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra 
Application number: 20030204095
Abstract: The present invention provides a process for the preparation of 4-methyl-5-formyl-thiazole of the formula (I) 1
Type: Application
Filed: December 5, 2002
Issued: October 30, 2003
Assignee: Orchid Chemicals & Pharmaceuticals Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Rajesh Vyas, Ramakrishna Kamma
Application number: 20030199712
Abstract: The present invention relates to a process for the preparation of 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) 1
Type: Application
Filed: September 18, 2002
Issued: October 23, 2003
Assignee: Orchid Chemicals and Pharmaceuticals Limited
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Pratik Ramesh Sathe, Sivakumaran Sundaravadivelan, Praveen Nagesh Ganesh
Patent number: 6610845
Abstract: The present invention provides new thioester derivatives of thiazolyl acetic acid of the general formula (I), wherein, R1 represents H, trityl, CH3, CRaRbCOOR2 (Ra and Rb independently of one another represents hydrogen or methyl and R2 represents H or C1-C4 alkyl). also, the invention provides a method by which the said thioester derivatives can be prepared by reacting thiazolyl acetic acid of the general formula (IV) with 1,2,5,6 tetrahdro-2-methyl-5,6 dioxo-1,2,4-triazin-3-thiol of the formula (VI) in a solvent, in presence of an organic base and with the help of Vilsmeier reagent of the formula (V). The so obtained thioester derivatives are reacted with 7-amino-cephem carboxylic acids of the general formula (III) to produce cephalosporin antibiotic compounds having the general formula (II).
Type: Grant
Filed: January 4, 2002
Issued: August 26, 2003
Assignee: Orchid Chemicals & Pharmaceuticals Limited, India
Inventors: Pandurang Balwant Deshpande, Pramod Narayan Deshpande, Shanmugam Srinivasan, Parven Kumar Luthra, Gautam Kumar Das 
Patent number: 6555680
Abstract: The present invention relates to a process for the preparation of sodium salt of Ceftiofur as given in Formula I, directly from its amine salt using sodium base.
Type: Grant
Filed: December 10, 2001
Issued: April 29, 2003
Assignee: Orchid Chemicals & Pharmaceuticals Ltd.
Inventors: Pandurang Balwant Deshpande, Pramod Narayan Deshpande, Milind Ramkrishna Kulkarni, Parven Kumar Luthra
Patent number: 6388070
Abstract: The present invention provides novel thioester derivatives of thiazolyl acetic acid of the general formula (I), wherein, R1 represents H, trityl, CH3, or CRaRbCOOR3, in which Ra and Rb, independently of one another, represents hydrogen or methyl and R3 represents H or C1-C7 alkyl; and R2 represents C1-C4 alkyl or phenyl.
Type: Grant
Filed: January 5, 2001
Issued: May 14, 2002
Assignee: Orchid Chemicals & Pharmaceuticals Ltd.
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra
Patent number: 6384215
Abstract: The present invention provides new thioester derivatives of 4-halogeno-2-methoxyimino-3-oxo-butyric acid of the general formula (I), also, the invention provides a method by which the said thioester derivatives can be prepared by reacting 4-halogeno-2-methoxyimino-3-oxo-butyric acid of the general formula (II) with 2-mercapto-5-substituted-1,3,4-oxadiazoles of the general formula (III) in a solvent, in the presence of DMF/POCl3 and in presence of an organic base and if desired the so obtained thioester derivatives so obtained are reacted with 7-amino-cephem carboxylic acids of the general formula (V) to produce condensed products which are insitu reacted with thiourea to get cephalosporin antibiotic compounds having the general formula (VI).
Type: Grant
Filed: June 7, 2001
Issued: May 7, 2002
Assignee: Orchid Chemicals & Pharmaceuticals Ltd.
Inventors: Pandurang Balwant Deshpande, Parven Kumar Luthra 
 WO2013001511


Parven Luthra........June 21, 1970



/////////////Parven Luthra

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