Vice Dean for Students Affairs
Prof. Tarek Aboul-Fadl Mohammad Hassan
Professor, Department of Medicinal Chemistry
Department of Department of Medicinal Chemistry
Faculty of Pharmacy, Assiut University
Fadl@aun.edu.eg
tarek.hassan@pharm.au.edu.eg
http://scholar.google.com.eg/citations?user=e2ALmfAAAAAJ&hl=en
Educational Qualifications:
- Ph. D. In Pharmaceutical Sciences ( Pharmaceutical Medicinal Chemistry ) , Faculty of Pharmacy, Assiut University - Egypt and Josai University, Saitama, Japan under the channel system and joint supervision scheme, 1994
- M. Sc. In Pharmaceutical Sciences ( Pharmaceutical Chemistry ) , Faculty of Pharmacy, Assiut University, 1989
- B. Sc. In Pharmaceutical Sciences , Faculty of Pharmacy, Assiut University, 1984
positions
- Professor, Department of Medicinal Chemistry , Faculty of Pharmacy, Assiut University, 2004
- Associate Professor, Department of Medicinal Chemistry , Faculty of Pharmacy, Assiut University, 1999
- Demonstrator, Department of Medicinal Chemistry , Faculty of Pharmacy, ِِAssiut University, 1984
Research fields:
Amantadine Amides Prodrugs, Hepatic Delivery Systems, Anticancer Agents, Spectrometric Monitoring, Microwave-Assisted Solution-Phase Synthesis, Potential Anti-tubercular Activity, Solution-Phase Synthesis
| Publications: | ||
| 1
- Ahmed M. Galal Osman, Ehab A. Abourashed, Desmond Slade, Safwat A.
Ahmed, Waseem Gul, Shabana I. Khan, Tarek Abo Elfadl, Olivia R. Dale,
Afeef S. Husni, Stephen J. Cutler, Mahmoud A. ElSohly. , Synthesis and
In Vitro Evaluation of Ferutinol Aryl Esters for Estrogenic Activity and
Affinity Toward Cannabinoid Receptors, Medicinal Chemistry Research ,
Springer, Vol. 24, pp. 2670-2678 , DOI 10.1007/s00044-015-1319-7, NULL,
2015 | ||
| 2
- Tarek Aboul-Fadl, Suliman S. Al-Hamad, Kevin Lee, Nan Li, Bernard D.
Gary, Adam B. Keeton, Gary A. Piazza, Mohammed K. Abdel-Hamid, Novel
Non-Cyclooxygenase Inhibitory Derivatives of Naproxen for Colorectal
Cancer Chemoprevention, Med. Chem. Res, DOI 10.1007/s00044-014-0979-z,
Springer, Vol.23, PP.4177-4188 , http://link.springer.com/journal/44,
2014 | ||
| 3
- Tarek Aboul-Fadl, Tilal Elsaman, Omar A. Al-Deeb, Hazem A. Ghabbour,
C. S. Chidan Kumar, Fun Hoong Kun, Some New NSAIDs Prodrugs: An
Efficient Synthesis, Spectral Characterization and X-ray Crystal
Structure Studies, Asian J. Chem. , Vol.26, No.16, PP.5249-5254,
http://dx.doi.org/10.14233/ajchem.2014.16949, July, 2014 | ||
| 4
- A.A. Radwan, T. Aboul-Fadl, A. Al-Dhfyan, W.M. Abdel-Mageed,
Synthesis and Characterization of bis-3,5-Disubstituted
Thiadiazine-2-thione Derivatives as Anticancer Agents, Asian J. Chem.,
Vol. 26, No. 23, pp. 8145-8150,
http://dx.doi.org/10.14233/ajchem.2014.17636, 2014 | ||
| 5 - Samy Emara, Tarek Aboul-Fadl, Abdel Nasser El-Shorbagy, Maha Kamal, Walaa Zarad, Mohamed Abdel Kawi, A Combined Experimental Green Flow-Injection Procedure and Computational Analysis to Determine Amino Acids, American Chemical Science Journal, SCIENCEDOMAIN international, 3 - 4, 419-433, http://www.sciencedomain.org/issue.php?iid=242&id=16, 2013 | ||
| 6 - Hatem A. Abdel-Aziz, Tarek Aboul-Fadl,
Abdul-Rahman M. Al-Obaid, Mohamed Ghazzali, Abdullah Al-Dhfyan,
Alessandro Contini, Design, Synthesis and Pharmacophoric Model Building
of Novel Substituted Nicotinic Acid Hydrazones with Potential
Antiproliferative Activity, Arch Pharm. Res., DOI:
10.1007/s12272-012-0904-2, Vol. 35, No. 9, pp. 1543-1552, 2012 | ||
| 7 - Tarek Aboul-Fadl, Suliman S. Al-Hamad, Mohammed K. Abdel-Hamid, Hatem A. Abdel-Aziz, Abdel-Rahman M. Al-Obaid, Jason D. Whitt, Bernard D. Gary, Adam B. Keeton and Gary A. Piazza. , Novel amino acid derivatives of naproxen for colon cancer chemoprevention. , 243rd American Chemical Society meeting, San Diego, California -USA , ACS, March, 2012 | ||
| 8
- Awwad A. Radwan, Abdullah Al-Dhfyan, Mohammed K. Abdel-Hamid,
Abdullah A. Al-Badr, Tarek Aboul-Fadl, 3,5-Disubstituted
Thiadiazine-2-thiones: New Cell-Cycle Inhibitors, Archives of Pharmacal
Research , Springer International Publishing AG, Vol. 35, No. 1, pp.
35-49, NULL, 2012 | ||
| 9
- Tarek Aboul-Fadl, Awwad A. Radwan, Mohamed Attia, Abdullah Al-Dhfyan,
Hatem A. Abdel-Aziz, Schiff Bases of Indoline-2,3-Dione (Isatin) with
Potential Antiproliferative Activity, Chem. Cent. J., doi:
10.1186/1752-153X-6-49, Vol. 6, No. 1, p. 49,
http://journal.chemistrycentral.com/content/pdf/1752-153X-6-49.pdf, 2012 | ||
| 10
- Tarek Aboul-Fadl, Awwad A. Radwan, Hatem A. Abdelaziz, Mohd.
Baseeruddin, Mohamad I. Attia, Adnan Kadi, Novel Schiff Bases of
Indoline-2,3-Dione and Nalidixic Acid Hydrazide: Synthesis, In Vitro
Antimycobacterial and In Silico Mycobacterium Tuberculosis (Mtb) DNA
Gyrase Inhibitory Activity, Digest Journal of Nanomaterials and
Biostructures, Vol. 7, No. 1, pp. 327-336,
http://www.chalcogen.infim.ro/329_Fadl.pdf, 2012 | ||
| 11
- Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Mohammed K. Abdel-Hamid, Tilal
Elsaman, Jane Thanassi, Michael J. Pucci, Schiff Bases of
Indoline-2,3-dione: Potential Novel Inhibitors of Mycobacterium
Tuberculosis (Mtb) DNA Gyrase., Molecules , NULL, Vol. 16, pp.
7864-7879, NULL, 2011 | ||
| 12 - Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Abdul-Rahman M. Al-Obaid, Abdullah Al-Dhfyan and Alessandro Contini. , Design and Synthesis of substituted Nicotinic Acid Hydrazones With Potential Antiproliferative Activity. , The 66th Northwest Regional Meeting of The American Chemical Society (NORM 2011), Portland, Oregon-USA, American Chemical Society , June, 2011 | ||
| 13 - Tarek Aboul-Fadl, Mahmoud M. Sheha,
Adel S. El-Azab, Hatem A. Abdel-Aziz, Amantadine Amides Prodrugs as
Hepatic Delivery Systems to Enhance its Activity Against HCV, Digest
Journal of Nanomaterials and Biostructures, the Academy of Romanian
Scientists, Vol. 6, No. 4, pp. 1675-1683,
http://www.chalcogen.infim.ro/1675_Fadl.pdf, 2011 | ||
| 14
- Hoong-Kun Fun, Madhukar Hemamalini, Hatem A. Abdel-Aziz, Tarek
Aboul-Fadl, (Z)-Ethyl
2-cyano-2-{2-[5,6-dimethyl-4-(thiophen-2-yl)-1H-pyrazolo[3,4-b]-pyridin-3-yl]-hydrazinylidene}acetate,
Acta Cryst., doi: 10.1107/S1600536811028911, E67, pp. o2145-o2146 ,
journals.iucr.org/e/issues/2011/08/00/is2753/is2753.pdf, 2011 | ||
| 15
- Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Adnan Kadi, Ahmed Bari, Pervez
Ahmad, Tilal Al-Samani, Seik Weng Ng, Microwave-Assisted One-Step
Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids,
Molecules, doi: 10.3390/molecules16053544, Vol. 16, pp. 3544-3551,
http://www.mdpi.com/1420-3049/16/5/3544/, 2011 | ||
| 16
- Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Adnan Kadi, Pervez Ahmad,
Tilal Elsaman, Mohamed W. Attwa, Ibrahim A. Darwish, Microwave-Assisted
Solution-Phase Synthesis and DART-Mass Spectrometric Monitoring of a
Combinatorial Library of Indolin-2,3-dione Schiff Bases with Potential
Antimycobacterial Activity, Molecules, doi: 10.3390/molecules16065194,
Vol. 16, pp. 5194-5206, http://www.mdpi.com/1420-3049/16/6/5194/, 2011 | ||
| 17
- Jessica J. Kempe-Dustin, Tarek Aboul-Fadl, Clarissa Christensen,
Robert Palais, Krishna Parsawar, Gerald J. Gleich, Lori A. Wagner, Cell
Screening Assay for Identifying Inhibitors of Eosinophil Proliferation,
Drug Dev. Res., DOI: 10.1002/ddr.20438, WILY, Vol. 72, pp. 353-360,
http://onlinelibrary.wiley.com/doi/10.1002/ddr.20438/abstract, 2011 | ||
| 18 - Wesam S. Abdel-Aal, Hoda Y. Hassan, Tarek Aboul-Fadl, Adel F. Youssef, Pharmacophoric Model Building for Antitubercular Activity of the Individual Schiff Bases of Small Combinatorial Library, European Journal of Medicinal Chemistry, vol. 45, pp. 1098 - 1106, 2010 | ||
| 19 - Ibrahim A. Darwish, Tarek Aboul-Fadl, Nasr Y. Khalil, Ashraf M. Mahmoud, Abdul-Rahman M. Al-Obaid , New Sensitive HPLC Method for Evaluation of the Pharmacokinetics of New Amantadine Prodrugs as Hepatic Delivery Systems to Enhance its Activity against HCV, Int. J. Res. Pharm. Sci, 1(2), 151-157, www.ijrps.pharmascope.org, April, 2010 | ||
| 20 - Abdelwareth A. O. Sarhan, Abdullah Al-Dhfyan, Maha A. Al-Mozaini, Chaker N. Adra, and Tarek Aboul-Fadl, Cell Cycle Disruption and Apoptotic Activity of 3-Aminothiazolo[3,2-a]benzimidazole-2-carbonitrile and its homologues, Eur. J. Med. Chem., Elsevier, 45, 2689-2694, June, 2010 | ||
| 21 - Tarek Aboul-Fadl and Fayzah A. S. Bin-Jubair, Anti-Tubercular Activity of Isatin Derivatives. , Int. J. Res. Pharm. Sci. , 1(2), 113-126 , www.ijrps.pharmascope.org, April, 2010 | ||
| 22 - Tarek Aboul-Fadl, Fayzah A. S. Bin-Jubair and Omima Aboul-Wafa. , Schiff Bases of Indoline-2,3-dione (Isatin) Derivatives and Nalidixic Acid Carbohydrazide, Synthesis, Antitubercular Activity and Pharmacophoric Model Building. , Eur. J. Med. Chem., 45, 4578-4586, 8, 2010 | ||
| 23 - Wael M. El-Sayed, Tarek Aboul-Fadl and Michael R. Franklin. , Effects of Isatin-Isoniazid Derivatives on Drug Metabolizing and Chemoprotective Enzymes in Mice. , Drug Development Research , 71(5), 313-322, July, 2010 | ||
| 24 - Tarek Aboul-Fadl, Hatem A. Abdul-Khader, Adnan Khadi, Ibrahim Darwish, Telal Al-Samani, Pervez Ahmad, Ahmed Bari and Sahal Al-Hajoj. , Design and Synthesis of a Combinatorial Library of Indoline-2,3-dione Schiff bases with Potential Anti-tubercular Activity. , 46th International Conference on Medicinal Chemistry (RICT 2010), Reims-France, June 30 -July 2, 2010., July, 2010 | ||
| 25 - Fayzah A. S. Bint-Jubair, Omima Aboul-Wafa and Tarek Aboul-Fadl. , Schiff Bases of Indol-2,3-dione (Isatin) Derivatives and Nalidixic Acid Hydrazidewith Potential Antitubercular Activity. , The 8th Saudi International Pharmaceutical Conference and Exhibition, Riyadh-Saudi Arabia, April 26-28, 2010., April, 2010 | ||
| 26 - Hatem A. Abdel-Aziz, AhmedBari, T. Aboul-Fadl and Seik Weng Ng. , (Z)-3Hydrazinylidene-1-phenylindolin-2-one. , Acta Crystallographica Section E, 66(11), o3014, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009040/?tool=pmcentrez, November, 2010 | ||
| 27 - Wesam S. Abdel-Aal, Hoda Y.Hassan, Tarek Aboul-Fadl and Adel F. Youssef, Solution-Phase Synthesis of Small Schiff Bases Combinatorial Library with Potential Antitubercular Activity, Der Pharma Chemica, 1 (2), 1- 13, www.derpharmachemica.com, 2009 | ||
| 28 - Ashraf M. Mahmoud, Nasr Y. Khalil, Ibrahim A. Darwish, Tarek Aboul-Fadl, Selective Spectrophotometric and Fluorometric Method for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with Sodium 1,2- Naphthoquinone-4-Sulphonate, Intl. J. Anal. Chem, Hindawi Publishing Corporation, 1-9, 2009 | ||
| 29 - Ibrahim A. Darwish, Ashraf M. Mahmoud, Tarek Aboul-Fadl, Abdul-Rahman A. Al-Majed, Nasr Y. Khalil , A highly sensitive enzyme immunoassay for evaluation of 2_-deoxycytidine plasma level as a prognostic marker for breast cancer chemotherapy, Analytica Chimica Acta, 632, 266–271, 2009 | ||
| 30 - Ahmed Galal, Safwat Ahmed, Ehab A. Abourashed, Desmond Slade, Waseem Gul, Shabana Khan, Tarek Aboul-Fadl and Mahmoud A. ElSohly., Antimicrobial and Estrogenic Activity of Ferutinin and Selected Semi-Synthetic Analogs. , The 50th Anniversary Meeting of the American Society of Pharmacognosy, Honolulu, HI-USA, June 27-July 1, 2009., June, 2009 | ||
| 31 - Tarek Aboul-Fadl , Ashraf M. Mahmoud, Nasr Y. Khalil, Ibrahim A. Darwish and Abdul-Rahman Al-Obaid , Evaluation of The Pharmacokinetic of New Amantadine Prodrugs As Hepatic Delivery Systems to Enhance Its Activity Against HCV by A New HPLC Method. , 237th American Chemical Society meeting, Salt Lake City, Utah-USA, March 22-26, 2009., March, 2009 | ||
| 32 - Ahmed Galal, Safwat Ahmed, Ehab A. Abourashed, Desmond Slade, Waseem Gul, Shabana Khan, Tarek Aboul-Fadl and Mahmoud A. ElSohly., Preparation, Antimicrobial and Estrogenic Activity of Ferutinin and Selected Analogs., The annual meeting of the National Center for Natural Products Research of the University of Mississippi, University of Mississippi-USA, January 2009., January, 2009 | ||
| 33 - Wesam S. Abdel Aal, Hoda Youssef, *Tarek Aboul-Fadl, M.O. Khalid, Adel F. Youssef, Design, Synthesis and Antitubercular Evaluation of Small Schiff Base Combinatorial Library, The 7th International Saudi Pharmaceutical Conference, March, 2008 | ||
| 34 - Tarek Aboul-Fadl, Gopalan Rajeev Kallanthottathil and Arthur D. Broom, Synthesis of a Peptide Nucleic Acid with a Novel 1-Methyl-6-mercaptopurine Base, J. Heterocyclic Chem., 45, 445-451, 2008 | ||
| 35 - Dorinda D Arch, Wael M El-Sayed, Tarek Aboul-Fadl, Jeannette C Roberts and Michael R Franklin , Regulation of ATP-binding cassette (Abc) transporters by organoselenium compounds, The FASEB , 22, 921, 2008 | ||
| 36 - Tarek Aboul-Fadl, Selenium Derivatives as a Cancer Preventive Agents. , 2nd World Conference on Magic Bullets (Ehrlich II). Nürnberg, Germany, October 3 - 5, 2008. , October, 2008 | ||
| 37 - M. R. Franklin, P. J. Moos, W. M. El-Sayed, T. Aboul-Fadl, J.C. Roberts , Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse , Chem-Biol Interactions, 168, 211–220, 2007 | ||
| 38 - Wael M. El-Sayed, Tarek Aboul-Fadl, Jeanette C. Roberts, John G. Lamb and Michael R. Franklin, Murine Hepatoma (Hepa1c1c7) Cells: A Responsive In Vitro System for Chemoprotective Enzyme Induction by Organoselenium Compounds , Toxicology in Vitro, 21, 157-164, 2007 | ||
| 39 - M.R. Franklin, J.C. Roberts, W.M. El-Sayed, T. Aboul-Fadl, T. Schofield, J.E. Constance and J.G. Lamb. , Chemoprevention in mice by 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids. , The 46th Annual Meeting (SOT), Charlotte, NC-USA, March 2007. , SOT, Abstract 609, Toxicological Sciences p126S., March, 2007 | ||
| 40 - Wesam S. Abd-el Aal, Hoda Y. Hassan, Tarek Aboul-Fadl , Adel F. Youssef. , Design, Synthesis and Antitubercular Evaluation of Small Schiff Base Combinatorial Library. , The 7th International Saudi Pharmaceutical Conference. Riyadh-Saudi Arabia, March 19-21 2007. , Saudi Pharmaceutical Society, March, 2007 | ||
| 41 - Tarek Aboul-Fadl, Antisense Oligonucleotide Technologies in Drug Discovery. , Expert Opin. Drug Discov, 1, 285-288, January, 2006 | ||
| 42 - Maria Arballo, Latoya Cooks, Jenny Gomes, Tiara Williams, Tarek Aboul-Fadl and Jeanette Roberts, Sensitivity of Escherichia coli to L-selenaproline and other L-proline analogues in laboratory culture media and normal. human urine Charles Deutch., Letters in Applied Microbiology , 43, 392–398, 2006 | ||
| 43 - Wael M. El-Sayed, Tarek Aboul-Fadl, John G. Lamb, Jeanette C. Roberts, and Michael R. Franklin. , Acute Effects of Novel Selenazolidines on Murine Chemoprotective Enzymes. , Chemico-Biological Interactions , 162, 31-42 , 2006 | ||
| 44 - Abdel-Wareth A.O. Sarhan, Shams H. Abdel-Hafez, Hassan El-Sherif and Tarek Aboul-Fadl, The Utility and Synthetic Uses of Mannich Reaction: An efficient Route for Synthesis of Thiadiazino-[1,3,5][3,2-a]Benzimidazoles. , Synthetic Communications , 36, 987 - 996 , 2006 | ||
| 45 - Wael M. El-Sayed, Tarek Aboul-Fadl, John G. Lamb, Jeanette C. Roberts, Michael R. Franklin , Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice. , Toxicology, 220, 179–188 , 2006 | ||
| 46 - Safwat M. Rabea, Nawal A. El-Koussi, Hoda Y. Hassan, Tarek Aboul-Fadl , Synthesis of 5-Phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic Acid Derivatives of Potential Anti-inflammatory Activity. , Arch. Pharm. Chem.Life Sci., 339, 32-40, 2006 | ||
| 47 - Wael M. El-Sayed, Tarek Aboul-Fadl, John G. Lamb, Jeanette C. Roberts and Michael R. Franklin. , Effects of acute exposure of selenazolidines prodrugs of L-selenocysteine on chemoprotective enzymes in mice and Hepa1c1c7 cells. , The 45th Annual Meeting of the Society of Toxicology (SOT), San Diego, California-USA, March 5-9, 2006., SOT, March, 2006 | ||
| 48 - Michael R. Franklin, Jeanette Roberts, Tarek Aboul-Fadl, Preparation of prodrugs and conjugates of thiol- and selenol-containing compounds. , U.S. Pat. Appl. Publ. , (Patent), 20 pp , 2005 | ||
| 49 - Tarek Aboul-Fadl, Selenium Derivatives as Cancer Preventive Agents. ‘A Review Article’. , Current Medicinal Chemistry-Anti-Cancer Agents, 5, 637-52 , 2005 | ||
| 50 - Tarek Aboul-Fadl, Antisense Oligonucleotides: The State of the Art ‘A Review Article’. , Current Medicinal Chemistry , 12, 2193-2214, 2005 | ||
| 51 - Mostafa A. Hussein, Tarek Aboul-Fadl and Asmaa Hussein, Synthesis and Antitubercular Activity of Some Mannich bases Derived from Isatin Isonicotinic acid hydrazone. , Bull. Pharm. Sci., Assiut University, Assiut University, 28, 131-136 , 2005 | ||
| 52 - Wael M. El-Sayed, Tarek Aboul-Fadl, John G. Lamb, Jeanette C. Roberts and Michael R. Franklin. , The biological effects of selenocysteine prodrugs. , Annual Bioscience Symposium, University of Utah, Salt Lake City, Utah-USA, September 9, 2005., September, 2005 | ||
| 53 - C. E. Deutch, M. E. Arballo, L. N. Cooks, J. M. Gomes, T. M. Williams, T. Aboul-Fadl, and J. C. Roberts. , Uptake of L-Selenaproline by the L-Cystine Transport System in Escherichia coli., 105th General Meeting of the American Society for Microbiology, Atlanta, Georgia, USA, June 5-9, 2005., June, 2005 | ||
| 54 - Tarek Aboul-Fadl, Wael M. El-Sayed, Tenley Schofield, Jonathan Constance, John G. Lamb, Jeanette C. Roberts, and Michael R. Franklin. , Hepatic effects of novel selenazolidine prodrugs of selenocysteine developed as potential cancer chemopreventive agents. , 229th ACS National Meeting, San Diego, California, USA, March 13-17, 2005. , ACS, March, 2005 | ||
| 55 - Tarek Aboul-Fadl, Vijai K. Agrawal, Robert W. Buckheit Jr. and Arthur D. Broom, An Unusual “Senseless” 2’-5’ Oligoribonucleotide with Potent Anti-HIV Activity. , Nucleosides, Nucleotides & Nucleic Acids , 23, 545-554, 2004 | ||
| 56 - Mostafa A. Hussein, Tarek Aboul-Fadl, Mahrous Osman, Mohamed Hassan and Mohamed Hashem. , Optical Isomers of 3-substituted-5-(2-carboxyethyl)-1,3,5- thiadiazin-2-thiones of Potential Antimicrobial Activity, Synthesis, and Solid State Stability. , Egyptian J. of Biomedical Sciences , 16, 194-209, 2004 | ||
| 57 - Wael M. El-Sayed, Tarek Aboul-Fadl, Ronald B. McEwen, Tenley Schofield, John G. Lamb, Jeanette C. Roberts and Michael R. Franklin. , Phase II Drug Metabolizing Enzyme mRNA Changes by Novel Selenazolidine Prodrugs of Selenocysteine in Mice., The 22nd Annual Meeting of the Mountain West Society of Toxicology (MWSOT), Park City – Utah, USA. September 9-10, 2004. , September, 2004 | ||
| 58 - Tarek Aboul-Fadl, Fargany A. Mohammed and Ehssan A. Hassan , Synthesis, Antitubercular Activity and Pharmacokinetic Studies of Some Schiff Bases Derived from 1- Alkylisatin and Isonicotinic Acid Hydrazide (INH). , Archives of Pharmacal Research, 26, 778-784, 2003 | ||
| 59 - Sahar Mahmoud, Tarek Aboul-Fadl, Mahmoud Sheha, Hassan H. Farag and Abdel-Maboud I. Mouhamed., 1,2-Dihydroisoquinoline-N-Acetic Acid Derivatives as New Carriers for Specific Brain Delivery I : Synthesis and Estimation of Oxidation Kinetics Using Multivariate Calibration Method., Arch. Pharm.Pharm. Med. Chem. , 336, 573-584, 2003 | ||
| 60 - Sahar Mahmoud, Mahmoud Sheha, Tarek Aboul-Fadl, and Hassan H. Farag., 1,2-Dihydroisoquinoline-N-acetic acid Derivatives as New Carriers for Brain Specific Delivery II: Delivery of Phenethylamine as Model Drug. , Arch. Pharm.Pharm. Med. Chem., 336, 526-531, 2003 | ||
| 61 - Mostafa Hussein, Tarek Aboul-Fadl and Asmaa Abdel-Nasser. , Synthesis and Antitubercular Activity of some Schiff Bases Derived from Mannich Bases of Isatin and Isonicotinic Acid Hydrazide (INH)., Polish-Austrian-German-Hungarian-Italian Joint Meeting on Medicinal Chemistry, KrakÓw, Poland 15-18 October 2003. , October, 2003 | ||
| 62 - Tarek Aboul-Fadl, Vijai Agrawal, Robert W. Buckheit Jr and Arthur D. Broom. , 2Unusual “Senseless” 2’-5’ Oligoribonucleotide with a Potent Anti-HIV Activity. , The 1st International Congress of Pharmaceutical and Drug Industries Division, National Research Center, Cairo-Egypt, March 24-26(2003)., March, 2003 | ||
| 63 - Aboul-Fadl, T. and Khallil, A. M. , Synthesis, degradation kinetics and in-vitro antimicrobial activity of tetrahydro-2H-1,3,5-thiadiazine-2-thion derivatives of some B-amino acids. , Arzneim. Forsch. Drug Res. , 53 (7):, 526 – 531., 2003 | ||
| 64 - Tarek Aboul-Fadl and Abdel-Raouf Khallil., Synthesis, Degradation kinetics and In-vitro Antimicrobial Activity of Tetrahydro-2H-1,3,5- thiadiazine-2-thione Derivatives of Some b-Amino Acids., Arzneim-Forsch./Drug Res., 526-531, 2002 | ||
| 65 - Tarek Aboul-Fadl and Mahrous Osman., Tetrahydro-2H-1,3,5- thiadiazin-2-thione Derivatives of The optical Isomers of Phenylalanine, Synthesis, Comparative Stability Study and Antifungal Activity. , Sci. Pharm., 70, 359-378, 2002 | ||
| 66 - Tarek Aboul-Fadl, Mostafa A. Hussein, Abdel-Nasser El-Shorbagi, and Abdel-Raouf Khallil., New 2H-Tetrahydro-1,3,5-thiadiazine-2-thiones Incorporating Glycine and Glycinamide as Potential Antifungal Agents. , Arch. Pharm.Pharm. Med. Chem. , 335, 438-442, 2002 | ||
| 67 - Mostafa I. Abd-Elrahman, Mahrous O. Ahmed, Sayed M. Ahmed, Tarek Aboul-Fadl and A.El-Shorbagi. , Kinetics of solid state stability of glycine derivatives as a model for peptides using differential scanning calorimetry. , Biophysical chemistry., 19, 113-20, 2002 | ||
| 68 - Stefan Löber, Tarek Aboul-Fadl, Harald Hübner and Peter Gmeiner. , Di- and Trisubstituted Pyrazolo[1,5-a]pyridine Derivatives: Synthesis, Dopamine Receptor Binding and Ligand Efficacy. , Bioorganic and Medicinal Chemistry Letters, 12, 633-636, 2002 | ||
| 69 - Tarek Aboul-Fadl, K.G. Rajeev and A.D. Broom., Synthesis of a Peptide Nucleic Acid with a Novel 1-Methyl-6-thiopurine Base. , 223 ACS meeting, Orlando, Florida-USA, April 6-11 (2002)., ACS, April, 2002 | ||
| 70 - Sahar M. Mohamoud, Mahmoud M. Sheha, Tarek Aboul-Fadl and Hassan H. Farag., 1,2-Dihydroisoquinoline Derivatives as New Carrier for Brain Specific Delivery., Assiut University Third Pharmaceutical Sciences Conference, Assiut-Egypt, March 5-6 (2002), March, 2002 | ||
| 71 - M.A. Hussein and T. Aboul-Fadl., Synthsis of New Optically Active Thiadiazine-2-thione Derivatives as Antifungal Agents., 8th IBN SINA Intrnational Conference on Pure and Apllied Heterocyclic Chemistry, Luxor-Egypt, Feb. 16-19 (2002)., February, 2002 | ||
| 72 - Atef A. Abdel-Hafez, Meselhy R. Meselhy, Norio Nakamura, Masao Hattori, Mahmoud A. El-Gendy, Nadia M. Mahfouz and Tarek A. Mohamed. , New Paeonilactone-A-Adducts Formed by Incubation of Paeoniflorin with Lactobacillus brevis in Presence of Arylthiols. , Chem. Pharm. Bull. , 49, 918-920, 2001 | ||
| 73 - Ahmed K. Dyab and Tarek Aboul-Fadl. , Antigiardial Activity of Metronidazole Twin Ester Prodrugs. , Zagazig University Medical Journal, VII(5), 1268-1275, 2001 | ||
| 74 - T. Aboul-Fadl, M.A. Hussein and A. A. El-Shorbagi., Synthesis and Antifungal Activity of Some New 3,5-Disubstiuted Tetrahydro-2H-1,3,5-Thiadiazine-2-Thione., XXVII Conference of Egyptian Pharmaceutical Society, Cairo - Egypt, January 2-4 (2001., January, 2001 | ||
| 75 - T. Aboul-Fadl, S. Löber and P. Gmeiner., Synthesis of 7-Substituted 3-[4(4-Chlorophenyl)-Piperazin-1-ylmethyl]-Pyrazolo[1,5-a]Pyridine Derivatives as Potential D4-Receptor Ligands., XXVII Conference of Egyptian Pharmaceutical Society, Cairo - Egypt, January 2-4(2001)., January, 2001 | ||
| 76 - Tarek Aboul-Fadl, Abdel-Nasser El-Shorbagi, Zeinab A. Hozien and Abdel-Wareth A.O. Sarhan. , Investigation of Alkylating, Antineoplastic and Anti-HIV Potentials of the Chalcones; 2-(3-Arylpropenoyl)benzimidazole and Their Corresponding N1-Methyl Derivatives. , Bollettino Chimico Farmaceutico. , 139, 228-234, 2000 | ||
| 77 - Tarek Aboul-Fadl, Stefan Löber and Peter Gmeiner. , Effective and Variable Functionalization of Pyrazolo[1,5-a]pyridines Involving Palladium-Catalyzed Coupling Reactions. , Synthesis , 12, 1727-1732, 2000 | ||
| 78 - F.A. Omar, N. M. Mahfouz and T. Aboul-Fadl. , Cyclic amide derivatives as potential prodrugs: N-hydroxymethyl-succinimide-/isatin esters of some NSAIDs as chemical delivery system with improved therapeutic index. , Eur. J. Med. Chem., 34, 551-562, 1999 | ||
| 79 - A. A. Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H. Watanabe, Y. Murakami. M. A. El-Gendy, N. M. Mahfouz and T. A. Mohamed., Anticonvulsant Activity of Paeonimetabolin-I Adducts Obtained by Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis. , Biol. Pharm. Bull., 22, 491-497, 1999 | ||
| 80 - T. Aboul-Fadl and K. Hassanin. , Tetrahydro-2H-1,3,5-thiadiazin-5-(4-pyridylcarboxamide)-2-thione Derivatives as prodrugs for Isoniazid, Synthesis, Investigations and In Vitro Antituberculous Activity. , Pharmazie , 54, 244-247, 1999 | ||
| 81 - T. Aboul-Fadl, M. M. Sheha and S. Khider. , Chitosan Conjugates of Ibuprofen and Flurbiprofen: Synthesis, Characterization and in vitro Stability. , Sci. Pharm. , 67, 27-41, 1999 | ||
| 82 - T. Aboul-Fadl and N. M. Mahfouz. , Metronidazole Twin Ester Prodrugs II : Non Identical Twin Esters of Metronidazole and Some Antiprotozoal Halogenated Hydroxyquinoline Derivatives. , Sci. Pharm., 66, 309-324, 1998 | ||
| 83 - A.A. Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H. Watanabe, Y. Murakami, M. A. El-Gendy, N. M. Mahfouz and T. A. Mohamed., Effects of Paeoniflorin Derivatives on the Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship. , Biol.Pharm.Bull., 21, 1174-1174, 1998 | ||
| 84 - N. M. Mahfouz, T. Aboul-Fadl and A. K. Diab. , Esters Twin Drugs of Metronidazole : Synthesis, Physicochemical properties, Kinetic studies and Antigardial activity. , Eur. J. Med. Chem., 33, 675-683, 1998 | ||
| 85 - T.A. Fadl and F. A. Omar. , Paracetamol (Acetaminophen) Esters of Some Non-steroidal Anti-inflammatory Carboxylic acids Drugs as Mutual Prodrugs with Improved Therapeutic Index. , Inflammopharmacology , 6, 143-157, 1998 | ||
| 86 - A.A. Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H. Watanabe, T. A. Mohamed, N. M. Mahfouz and M. A. El-Gendy. , Potent Anticonvulsant Paeonimetabolin-I Derivatives Obtained by Incubation of Paeoniflorin and Sulfhydryl Compounds With Lactobacillus Brevis., Chem.Pharm. Bull., 46, 1486-1487, 1998 | ||
| 87 - T. Aboul-Fadl, M. M. Sheha and S. Khider., Chitosan Conjugates of Ibuprofen and Flurbiprofen: Synthesis, Characterization and in vitro Stability., XXVI Conference of Egyptian Pharmaceutical Society, Cairo- Egypt, December 8-10(1998), December, 1998 | ||
| 88 - S. Emara and T. Aboul-Fadl., Flow injection analysis of amino acids using Cu(II) oxide as a packed reactor for ultraviolet detection., Fourth European Congress of Pharmaceutical Sciences, Milan-Italy, September 11-13(1998)., September, 1998 | ||
| 89 - F. A. Omar, N. M. Mahfouz and T. Aboul-Fadl. , Cyclic amide derivatives as potential prodrugs: N-hydroxmethyl-succinimide-/isatin esters of some NSAIDs as chemical delivery system with improved therapeutic index. , XIV Scientific Meeting of the Austrian Pharmaceutical Society, Graz - Austria, June 11-13(1998)., June, 1998 | ||
| 90 - T. Aboul-Fadl, W. Fleischhacker and E. Urban. , A Structurally Simplified Analogue of the Antibiotic Heptelidic Acid With a Five Membered Carbocyclic Ring. , XIV Scientific Meeting of the Austrian Pharmaceutical Society, Graz -Austria, June 11-13(1998), June, 1998 | ||
| 91 - T. Aboul-Fadl, N. M. Mahfouz and A. K. Diab., Metronidazle Twin Esters Prodrugs II : Non Identical Twin Esters of Metronidazole and Some Antiprotozoal Halogenated Hydroxyquinoline Derivatives., Assiut University First International Pharmaceutical Sciences Conference, Faculty of Pharmacy, Assiut-Egypt, March 4-5(1998), March, 1998 | ||
| 92 - aAhmed diab, Tarek aboel fasdel and Nadea M. mohafoz, metronidazole twin ester prodrugs : synthesis , physicchemical properties , hydrolysis kinetic and antigardial activity , Eur.J.Med. Chem. , 33.675, 675, 1998 | ||
| 93 - T. Aboul-Fadl and A. El-Shorbagi. , New Carriers for Representative Peptide Drugs. , Arch. Pharm.Pharm. Med. Chem. , 330, 327- 332, 1997 | ||
| 94 - Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H. Watanabe, T. A. Mohamed, N. M. Mahfouz and M. A. El-Gendy. , Modifications of Paeoniflorin and Paeonimetabolin I by Chemical and Biochemical Means. , International Symposium on Natural Medicines, Kyoto - Japan, October 28 -30(1997), October, 1997 | ||
| 95 - T. Kawaguchi, A.F.Youssef, T.Aboul-Fadl, F.A.Omar, H.H.Farag, and T.Hasegawa., Steric Parameters in PLE Catalyzed Hydrolysis of N4-substituted Cytarabine Esters Prodrugs. , Pharmazie, 51, 717-719, 1996 | ||
| 96 - T.Aboul-Fadl and A. El-Shorbagi., New Prodrug Approach for Amino Acids and Amino-Acid-Like Drugs. , Eur. J. Med. Chem., 31, 165-169, 1996 | ||
| 97 - T. Aboul-Fadl and E. A. Fouad., Synthesis and In Vitro Investigation of Nalidixic Acid Amides of Amino Acid Esters as Prodrugs. , Pharmazie, 51, 30-33, 1996 | ||
| 98 - T. Aboul-Fadl and A. El-Shorbagi., Tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives as new carriers for peptide drugs. , XXV Conference of Egyptian Pharmaceutical Society, Cairo- Egypt, December 24-26(1996), December, 1996 | ||
| 99 - T.A.Fadl, T.Hasegawa, A.F.Youssef, H.H.Farag, F.A.Omar and T.Kawaguchi., Synthesis and Investigation of N4-substituted Cytarabine Derivatives as Prodrugs. , Pharmazie, 50, 382-387, 1995 | ||
| 100 - T. Aboul-Fadl, A. El-Shorbagi, Z. Hozein and A. Sarhan. , Synthesis and Investigation of the Alkylating Potential of 2-(3-Arylpropen-oyl)benzimidazole and their Corresponding N1-methyl Derivatives. , Al-Azhar First International Conference on Recent Advances in Pharmaceutical Technology and Biological Sciences, Cairo - Egypt, December 19-21(1995), December, 1995 | ||
| 101 - T.Abo-El-Fadl, A. F. Youssef and A. N. Ahmed, 1HNMR and chelating properties of 1,5-dimethyl-N-substituted-1H-pyrazole-3- carboxamides and 1,3-dimethyl-N-substituted-1H-pyrazole-5-carboxamides., Pharmazie, 48, 117-120, 1993 | ||
| 102 - T.A.Fadl, T.Hasegawa, A.F.Youssef, H.H.Farag, F.A.Omar and T.Kawaguchi., Synthesis, Hydrolysis Kinetics, Lipophilicity, and Biological Activity of N4-(3-Alkoxy and Benzyloxycarbonylpropionyl)-Ara-C Prodrugs., World congress of Pharmacy and Pharmaceutical Sciences "FIP'93", Tokyo, Japan, September 5-10(1993), September, 1993 | ||
| 103 - T.A. Mohamed, A. F. Youssef and A. N. Ahmed, 1HNMR of Pyrazoles : effect of interaction of carbamoyl group with adjacent centers on the chemical shifts of concerned protons., Bull. Pharm. Sci., Assiut University, 15, 100-105, 1992 | ||
| 104 - T.A. Fadl, A. F. Youssef, A. N. Ahmed., 1HNMR and chelating properties of 1,5-dimethyl-N-substituted -1H- pyrazole-3-carboxamides and 1,3-dimethyl-N-substituted-1H- pyrazole-5-carboxamides., 3rd IBN SINA Symposium on Heterocyclic Chemistry, Aswan, Egypt, January 28-31(1991), January, 1991 | ||
| 105 - T.A. Fadl, A. F. Youssef, A. N. Ahmed and H. I. El-Bitar., Synthesis and Biological activity of certain 1,3- and 1,5-dimethyl-N-substituted pyrazole carboxamides., Bull. Pharm. Sci., Assiut University , 13, 145-158, 1990 | ||
| 106 - T. A. Fadl and F. A. Omar. , Acetaminophen Esters of Some Non-steroidal Antiinflammatory Drugs as Mutual Prodrugs with Improved Therapeutic Index., Assiut University First International Pharmaceutical Sciences Conference, Faculty of Pharmacy, Assiut-Egypt, March 4-5(1998), March, 1968 |
Address: كلية الصيدلة, Al Kasr Way, Qesm Than Asyut, Assiut Governorate, Egypt
Phone:+20 88 2080711
Asyut, Al Hamraa Ath Thaneyah, Qesm Than Asyut, Assiut Governorate, Egypt
Al Walideyah Al Westaneyah, Qesm Than Asyut, Assiut Governorate, Egypt .........above
عيادة الرحمة
Manqabad, Markaz Assiut, Assiut Governorate, Egypt
مدرسة منقباد الثانوية المشتركة
///////Assiut University, Department of Medicinal Chemistry, Prof. Tarek Aboul-Fadl Mohammad Hassan, Asyut, Al Hamraa Ath Thaneyah, Qesm Than Asyut, Assiut Governorate, Egypt
No comments:
Post a Comment