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Tuesday 21 April 2015

Dr. Emily Peterson





Emily Peterson, Ph.D., Amgen scientist and green chemistry team lead, applies green chemistry principles in her lab at Amgen's Cambridge Research facility.


  Genetic Engineering & Biotechnology News


read at http://www.genengnews.com/gen-articles/green-chemistry-initiatives-take-shape/3906/  

 links http://www.researchgate.net/profile/Emily_Peterson http://www.pubfacts.com/author/Emily+Peterson
https://www.linkedin.com/pub/emily-peterson/4/904/629  
  • Department of Medicinal Chemistry
    United States


http://www.pubfacts.com/author/Emily+Peterson

Summary

Medicinal Chemist with experience working in Oncology and Neuroscience. Leader of Green Chemistry team at the Amgen, Cambridge facility. Our effort is currently focused on incorporating the principles of Green Chemistry into drug discovery research. Specialties:Structure-based drug design, alkaloid synthesis
Emily Peterson

Education

 Emily Peterson

Experience



Senior Scientist

Amgen
March 2012 – Present (3 years plus) Cambridge, MA
Involved in lead optimization efforts (compound design and synthesis) on an ion channel project, overseeing external chemistry resources for the project. Chemistry lead for early-stage neuroscience project. Manager of one M.S. chemist and two Ph.D. contract workers at Amgen. Green Chemistry team leader for Medicinal Chemistry at Amgen, achieved reduction of dichloromethane usage at the site by over 60%. I represent Amgen Medicinal Chemistry on the ACS Green Chemistry Institute Pharmaceutical Round Table.
Map of cambridge ma


Scientist

Amgen
August 2007 – March 2012 (4 years 8 months)Cambridge, MA
Responsible for the design and synthesis of compounds for oncology and neuroscience projects in both the lead optimization and lead identification stages. Managed 1 B.S./M.S. chemist and a team of CRO chemists. Initiated and led the Drug Discovery Green Chemistry Team at the Amgen Massachusetts site. Involved in the interviewing and hiring of both Ph. D. and B.S./M.S. scientists.


Postdoctoral Fellow

Harvard University - Jacobsen Group
July 2005 – July 2007 (2 years 1 month)
Developed a method for the asymmetric addition of indoles to cyclic N-acyl iminium ions

Patents



Preparation of dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors

Europe WO 2013122897 A1 20130822
Filed August 22, 2013


Preparation of bicyclic aryl and heteroaryl sodium channel inhibitors

Europe WO 2013086229 A1
Filed June 13, 2013


Preparation of heteroaryl compounds as PIKK inhibitors for the treatment of cancer

Europe WO 2010132598
Issued November 18, 2010
zimidazole compounds as mTOR kinase inhibitors for the treatment of cancer


Europe WO 2010096314
Issued August 26, 2010


Fused heterocyclic derivatives as HGF modulators and their preparation and methods of use

Europe WO 2009091374
Issued July 23, 2009


Benzoimidazole derivatives as PI3 kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancers

United States US 20090163489
Issued June 25, 2009

Publications



Sustainable Chromatography (an oxymoron?)(Link)

Green Chemistry
July 15, 2014
Chromatography is routinely used in drug discovery as a means to isolate intermediates and final compounds. From a sustainability perspective, it is one of the largest contributors of solvent waste in the drug discovery process. The medicinal chemistry subgroup within the American Chemical Society's Green Chemistry Institute Pharmaceutical Roundtable (ACS GCI PR) offers a perspective aimed at...more


Sustainable Practices in Medicinal Chemistry: Current State and Future Directions.(Link)

Journal of Medicinal Chemistry
April 2013
The medicinal chemistry subgroup of the American Chemical Society’s Green Chemistry Institute Pharmaceutical Roundtable (ACS GCI PR) offers a perspective on the current state of environmentally sustainable practices in medicinal chemistry with the aim of sharing best practices more widely and highlighting some potential future developments.


Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.(Link)

Bioorganic & medicinal chemistry letters
August 1, 2012
mTOR is a critical regulator of cellular signaling downstream of multiple growth factors. The mTOR/PI3K/AKT pathway is frequently mutated in human cancers and is thus an important oncology target. Herein we report the evolution of our program to discover ATP-competitive mTOR inhibitors that demonstrate improved pharmacokinetic properties and selectivity compared to our previous leads. Through...more


A convenient guide to help select replacement solvent for dichloromethane in chromatography(Link)

Green Chemistry
August 20, 2012
One of the largest contributors to chlorinated solvent waste in medicinal chemistry is chromatography. A set of “drug-like” compounds was employed to compare the relative eluting strengths of greener solvent systems. Disclosed herein is an experimentally-derived solvent selection guide to aid chemists in choosing greener solvents for chromatographic purification, with a particular focus on...more


Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.(Link)

Bioorganic Medicinal Chemistry Letters
February 12, 2011
mTOR is part of the PI3K/AKT pathway and is a central regulator of cell growth and survival. Since many cancers display mutations linked to the mTOR signaling pathway, mTOR has emerged as an important target for oncology therapy. Herein, we report the discovery of triazine benzimidazole inhibitors that inhibit mTOR kinase activity with up to 200-fold selectivity over the structurally homologous...more


Facile preparation of protected benzylic and heteroarylmethyl amines via room temperature Curtius rearrangement(Link)

Tetrahedron Letters
May 26, 2010
A step-wise, room temperature procedure for acyl azide formation and the subsequent Curtius rearrangement of phenyl and heteroaryl acetic acids is described. We have developed a protocol for room temperature Curtius rearrangement in MeOH or CHCl3 that provides an improvement over standard conditions, avoiding the use of additives or heat. This room temperature optimization of the Curtius...more


Enantioselective, thiourea-catalyzed intermolecular addition of indoles to cyclic N-acyl iminium ions.(Link)

Angewandte Chemie International Edition
July 16, 2009
N-acyl iminium ion intermediates underwent intermolecular addition by these nucleophiles under the catalysis of a chiral thiourea Schiff base derivative. A variety of functionalized indole frameworks were assembled with high enantioselectivity from simple precursors by this method


Enantioselective Pictet−Spengler-Type Cyclizations of Hydroxylactams:  H-Bond Donor Catalysis by Anion Binding(Link)

Journal of the American Chemical Society
October 17, 2007
Highly enantioenriched indolizinone and quinolizinone products are obtained in the thiourea-catalyzed cyclization of tryptamine-derived hydroxylactams. Substituent and counterion effect studies point to a novel mechanism of catalysis involving rate-limiting anion abstraction and binding by the thiourea.


Synthesis of all low-energy stereoisomers of the tris(pyrrolidinoindoline) alkaloid hodgkinsine and preliminary assessment of their antinociceptive activity.(Link)

The Journal of Organic Chemistry
September 21, 2007
The previously unknown stereoisomers 3, 4, ent-1, and ent-4 of the tris(pyrrolidinoindoline) alkaloids hodgkinsine (1) and hodgkinsine B (2) were prepared by stereocontrolled total synthesis. In each synthesis, a catalyst-controlled intramolecular Heck reaction was the key step in appending a third cis-pyrrolidinoindoline ring to a hexacyclic chimonanthine precursor. Results of the preliminary...more


Synthesis of Dihydroquinolinones Angularly-Fused to Tetrahydrobenzazepinone Rings

Heterocycles
January 2006


Contiguous stereogenic quaternary carbons: a daunting challenge in natural products synthesis.(Link)

Proceedings of the National Academy of Sciences
August 17, 2004
One element of structure that invariably increases the difficulty of a chemical synthesis is the presence in the target molecule of contiguous all-carbon quaternary stereocenters. This Perspective will examine the most useful transformations and strategies devised recently for directly assembling this structural unit.


Synthesis of aromatic bisabolene natural products via palladium-catalyzed cross-couplings of organozinc reagents.(Link)

Journal of Organic Chemistry
May 2004
Aromatic bisabolene derivatives were prepared by two methods involving cross-coupling of organozinc reagents. The first synthesis of (±)-glandulone A (10), as well as syntheses of (±)-curcuhydroquinone (8) and (±)-curcuquinone (9), were accomplished via coupling of a secondary alkyl zinc reagent (1,5-dimethyl-4-hexenylzinc halide, 18) to protected bromohydroquinones using Pd(dppf)Cl2 as catalyst....more


Enantioselective synthesis of (−)-idiospermuline(Link)

Tetrahedron
August 25, 2003
The enantioselective total synthesis of the nonacyclic polypyrrolidinoindoline (−)-idiospermuline is described. Stereocontrolled formation of the vicinal quaternary carbon centers is achieved in a single step by dialkylation of an unsymmetrical prostereogenic dienolate with a tartrate-derived chiral dielectrophile. A catalyst-controlled diastereoselective Heck cyclization is employed to form the...more


Enantioselective total synthesis of the cyclotryptamine alkaloid idiospermuline.(Link)

Angewandte Chemie International Edition
June 5, 2003
Stereogenic quaternary carbons present the primary challenge in the syntheses of trispyrrolidinoindoline alkaloids such as idiospermuline. In its synthesis the two contiguous quaternary centers are expediently addressed by combining the lithium dienolate of a differentially protected dihydroisoindigo with a tartrate-derived electrophile. The third quaternary stereocenter is introduced by a...more


An expedient total synthesis of (±)-caparratriene(Link)

Tetrahedron Letters
July 2, 1999
(±)-Caparratriene has been synthesized by two succinct routes. The first relies on two Wittig reactions and produces (±)-caparratriene and its 2Z isomer as an inseparable 2:1 mixture. The second more efficient synthesis produces only the naturally occurring 2E isomer and proceeds in 36% overall yield. The key step in this short synthesis is the Suzuki coupling of E-2-bromo-2-butene with the E-...more

Brindar Sandhu




Brindar Sandhu at the UCB Amgen Scholars Poster Session ...

 

Brindar Sandhu



Email: brindar.sandhu@emory.edu https://www.linkedin.com/pub/brindar-sandhu/29/a79/a42 http://www.researchgate.net/profile/Brindar_Sandhu
   

Education



University of Michigan

B.S.E., Biomedical Engineering
2006 – 2010
Activities and Societies: Asha for Education, SWE, BMES

Experience



Graduate Student

Emory University
August 2011 – Present (3 years 9 months)Atlanta, GA
Genetics & Molecular Biology Ph.D. program
Dissertation topic: "Aminoglycoside phosphotransferases: Models for Enzyme Evolution" Rotation project, lab of Justin Gallivan, Ph.D.: "Creating a Theophylline-binding OFF-Riboswitch" Attempted to create a riboswitch utilizing an aptamer that changed secondary structure upon binding of the small molecule theophylline in the 5’ UTR, such that downstream translation of a reporter gene is inhibited Rotation project, lab of David Lynn, Ph.D.: "Selecting for Amyloid Production to Epigenetically Regulate Plasmid Copy Number" Developed a proposal based on the RepA plasmid replication protein, specifically a mutant version that induces the formation of amyloid, to regulate plasmid copy number through antibiotic selection and amyloid production Rotation project, lab of Ichiro Matsumura, Ph.D.: "Using Bacteria as a Sensor" Attempted to engineer the metal-reducing bacterium, Shewanella oneidensis, to act as a gating detection device to, upon addition of lactose, sense the small molecule, theophylline, and upon binding, transcribe and translate the lacY and lacZ genes and emit electrons that can be detected using a voltmeter


Social co-chair, Graduate Student Council

Emory University
August 2013 – Present (1 year 9 months)
Help plan, set-up, and execute mixers for Laney graduate students (4 per year) Facilitate cab reimbursement program with the Graduate Student Government Association (GSGA) Serve as a Laney representative to GSGA


President, Graduate Students in Genetics

Emory University
November 2013 – August 2014 (10 months)
Co-founded and currently aid in running the extracurricular group Graduate Students in Genetics, or GSIG. We hold monthly networking mixers in order to facilitate networking for those interested in genetics within the graduate school. GSIG is a chartered group through the Laney Graduate School's Graduate Student Council.


GMB Student Representative

Emory University
August 2013 – July 2014 (1 year)
Function as a liaison between faculty and students within the GMB program Serve on the recruitment and the retreat committee to help plan, set up, and run recruitment for incoming class as well as the annual program retreat


Teaching Assistant - BIOL 264: Genetics: A Human Perspective

Emory University
January 2014 – May 2014 (5 months)
Facilitate weekly class discussions
Graded three exams per semester along with another TA and the instructor.


Teaching Assistant - BIOL 370: Introduction to Microbiology

Emory University
August 2012 – December 2012 (5 months)Atlanta, GA
Graded weekly homework assignments and three exams throughout the semester for an undergraduate course of 130 students
Held review sessions in preparation for the three exams Held weekly office hours for assistance with homework assignments


Postbaccalaureate Research Fellow

National Institutes of Health
June 2010 – June 2011 (1 year 1 month)Bethesda, MD
National Institute of Diabetes and Digestive and Kidney Diseases Genetics of Simple Eukaryotes Section Laboratory of Biochemistry and Genetics
Ran a screen for URE2 mutations that prevent the Hsp40 Ydj1 from curing Ure2delta yeast cells of the [URE3] prion to deduce essential domain interactions for prion propagation in Saccharomyces cerevisiae Tested known mutations to the Hsp40 Sis1 that cause changes to the [PSI+] prion for phenotypic changes to the [URE3] prion in Saccharomyces cerevisiae


Grader, BiomedE 321: Bioreaction Engineering & Design

University of Michigan
January 2010 – April 2010 (4 months)Ann Arbor, MI
Department of Biomedical Engineering
Worked with the instructional aide, graduate student instructor, and the professors to grade homework assignments, exams, and regrade requests, return them to the students, and upload grades online


Undergraduate Research Assistant

University of Michigan Health System
May 2008 – April 2010 (2 years)Ann Arbor, MI
Urology Department
Project 1 (Sept 2009 – Apr 2010): “The Roles of Soluble E-Cadherin and EGFR in Prostate Cancer” Used timed experiments, immunoprecipitations, and western blots to analyze interaction of soluble E-Cadherin and EGFR in prostate cancer cell lines Project 2 (Jun 2008 – Apr 2009): “The Role of ADAM15 in the Metastatic Progression of Prostate Cancer” Examined the interaction of ADAM15 (A Disintegrin And Metalloproteinase) and EGFR family members and the AKT signaling pathway in LNCaP cells using western blots and immunoflourescence Presented results in oral presentation at conclusion of program Wrote final reports at the end of each semester summarizing data and conclusions Co-author on abstract submitted to American Association of Cancer Research: Advances in Prostate Cancer Research National Conference: “Activation of the Disintegrin Protease ADAM15 Leads to Cleavage of E-cadherin and Enhanced Signaling in Prostate Cancer Cells”


Amgen Scholar

University of California, Berkeley
June 2009 – August 2009 (3 months)Berkeley, CA
Department of Bioengineering
Project: “Induced Control of MLCK-Dependent Mechanobiology in Human Glioma Cells” Performed 2-D collagen gel, 3-D gel contraction, immunoflourescence and cell migration assays to demonstrate changes in tumor invasiveness properties in human glioma cells as myosin light chain kinase (MLCK) activity was varied using a tetracycline-off promoter construct Presented results in poster and oral presentations at conclusion of program Discussed research with other scholars and professional scientists at 2009 Amgen Scholars U.S. Symposium at UCLA (July 2009)


Summer Research Intern

University of Kansas
May 2007 – July 2007 (3 months)Lawrence, KS
Research Experience for Undergraduates Department of Chemical and Petroleum Engineering
Project: “Subcritical CO2-melded Poly(D,L-lactide-co-glycolide) Microsphere-based Tissue Scaffolds for Cartilage Tissue Engineering” Seeded novel tissue scaffolds with chondrocyte cells to determine feasibility for future osteochondral tissue engineering Tested strength of microsphere-based scaffolds with uniaxial compression tests Tested cell viability and cartilage formation with histological and immunohistochemical assays Presented results in the form of a poster at a university-wide poster symposium

Honors & Awards

NIH GMB Training Grant

Emory Genetics & Molecular Biology Ph.D. Program
August 2011

Courses

Emory University

  • Introduction to prokaryotic molecular genetics
  • Genetics of progenitor and stem cells
  • Eukaryotic chromosome organization & function
  • Model genetic systems
  • Ethical conduct in research
  • Hypothesis design & scientific writing
  • Introductory graduate seminar


Limin Wang, Milind Singh, Mihael Lazebnik, Michael Detamore, and Liang Zhao. Front Row: Ivy Tran, Brindar Sandhu, Jeannie Salash, and Jordan Christian.