DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair,With death on the horizon, This will not stop me, Gods call only..........
DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 29Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contributio
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Thursday, 20 April 2017

DR PRAVIN PATIL



Dr. Pravin C. Patil

Dr. Pravin C. Patil

Postdoctoral Research Associate at University of Louisville

LINKS




Email

pravinchem@gmail.comhttps://www.researchgate.net/profile/Pravin_Patil18/infohttps://www.linkedin.com/in/dr-pravin-c-patil-80741a5/https://www.facebook.com/pravinchem?lst=100000982203141%3A100002955527551%3A1492682395
  • Dr. Pravin C Patil completed his B.Sc. (Chemistry) at ASC College Chopda (Jalgaon, Maharashtra, India) in 2001 and M.Sc. (Organic Chemistry) at SSVPS’S Science College Dhule in North Maharashtra University (Jalgaon, Maharashtra, India) in year 2003.  

    During his research experience, he has authored 23 international publications in peer reviewed journals and inventor for 4 patents.
  • After M.Sc. degree he was accepted for summer internship training program at Bhabha Atomic Research Center (BARC, Mumbai) in the laboratory of Prof. Subrata Chattopadhyay in Bio-organic Division. 
  • In 2003, Dr. Pravin joined to API Pharmaceutical bulk drug company, RPG Life Science (Navi Mumbai, Maharashtra, India) and worked there for two years. In 2005, he enrolled into Ph.D. (Chemistry) program at Institute of Chemical Technology (ICT), Matunga, Mumbai, Maharashtra, under the supervision of Prof. K. G. Akamanchi in the department of Pharmaceutical Sciences and Technology. 
  • After finishing Ph.D. in 2010, he joined to Pune (Maharashtra, India) based pharmaceutical industry, Lupin Research Park (LRP) in the department of process development. 
  • After spending two years at Lupin as a Research Scientist, he got an opportunity in June 2012 to pursue Postdoctoral studies at Hope College, Holland, MI, USA under the supervision of Prof. Moses Lee. During year 2012-13 he worked on total synthesis of achiral anticancer molecules Duocarmycin and its analogs. 
  • In 2014, he joined to Prof. Frederick Luzzio at the Department for Chemistry, University of Louisville, Louisville, KY, USA to pursue postdoctoral studies on NIH sponsored project “ Structure based design and synthesis of Peptidomimetics targeting P. gingivalis.
  • During his research experience, he has authored 23 international publications in peer reviewed journals and inventor for 4 patents.

  • Ph.D. Organic chemist with significant experience in the field of academic research, postdoctoral studies and pharmaceutical industries.

    Specialties: 
    1. Good theory and practical knowledge of Organic Chemistry.
    2. Expertise in chiral resolution, racemization, purification techniques such as extraction, distillation, recrystallization and column chromatography.
    3. Worked on various organic reactions like Vilsmeier-Haack reaction, Knoevenagel condensation, Friedal-Crafts alkylation and acylation, Suzuki Coupling, Aldol condensation, Knorr Pyrrole synthesis, Grignard reaction, Oxidation, Reduction, Diazotization, Reductive alkylation, Hydrogenation etc.
    4. Expertise in multi-step organic synthesis of heterocyclic compounds based on quinoxaline, coumarin, benzoxazole, benzothiazole, benzimidazole, pyrroles, thiazole, pyridine, oxazole, thiophene, imidazole etc from milligram to kilogram scale.
    5. Experience in route scouting, route selection, process development, optimization, technology transfer to pilot plant and bulk synthesis of active pharmaceutical ingredients (APIs). 
    6. Expertise in literature survey using Sci-Finder, Cross Fire Beilstein, Chemical Abstracts (CA), Patents.
    7. Aware about the knowledge and functions of all spectroscopic techniques and instrumentation which are the essential part of research

HIGHLIGHTS
• Strong background in organic reaction mechanisms and contemporary synthetic methods.
• Wide range of experience in route scouting, optimization, process development, scale up, technology transfer and commercialization of APIs and intermediates.
• Experience in multi step organic synthesis of NCE molecules for pre-clincal trials following GMP guidelines.
• Expertise in synthesis of heterocyclic compounds based on oxazoles, coumarin, benzoxazole, benzothiazole, benzimidazole, highly sensitive pyrroles, thiazole, thiophene, imidazole.
• Characterization / Identification of API Impurities as a part of DMF filing process.
• Experience in laboratory scale high pressure reactions and catalytic hydrogenation.
• Expertise in techniques routinely used in synthetic organic chemistry laboratories, including analytical, preparative, and spectroscopic techniques like nuclear magnetic resonance, mass, infrared and purification techniques such as flash chromatography, recrystallization.
• Experience in writing scientific manuscripts, mentoring undergraduate students/Junior colleagues.



Current


Experience



Education



Tetrahedron Letters





14

Publications

  • publication titleSynthesis of extended oxazoles II: Reaction mniolds of 2-(halomethyl)-4,5 diaryloxazoles.

    publication descriptionTetrahedron Letters
    publication dateJan 10, 2016

    Authors

    Dr. Pravin C. PatilFrederick Luzzio
  • publication title

    AzaHx, a novel fluorescent, DNA minor groove and G·C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamide
    publication descriptionBioorganic Medicinal Chemistry Letters
    publication dateSep 1, 2015

    Authors

    Dr. Pravin C. PatilMoses LeeVijay Satambalaji babu
  • publication title

    Nuclear Localization and Gene Expression Modulation by a Fluorescent Sequence Selective p-Anisylbenzimidazolecarboxamido Imidazole-Pyrrole Polymide
    publication descriptionChemistry and Biology
    publication dateJul 23, 2015

    Authors

    Dr. Pravin C. PatilKonstantinos KiakosLuke PettVijay SatamDaniel HochhauserMoses LeeJohn A Hartley
  • publication title

    Oxazoles for click chemistry II: synthesis of extended heterocyclic scaffolds
    publication descriptionTetrahedron Letters
    publication dateNov 8, 2014

    Authors

    Dr. Pravin C. PatilFrederick LuzzioDonald Dumuth
  • publication title

    Simple and effective route for synthesis of parvaquone, an antiprotozoal drug
    publication descriptionRSC Advances
    publication dateOct 20, 2014

    Authors

    Dr. Pravin C. PatilKrishnacharya G. Akamanchi
  • publication title

    Inhibition of Human Glutathione Transferases by Dinitronaphthalene Derivatives
    publication descriptionArchives of Biochemistry and Biophysics
    publication dateJun 12, 2014

    Authors

    Dr. Pravin C. PatilMoses Lee

Dr. Pravin has 4 patents4

Patents

  • Patent titleA novel method for the synthesis of 2-alkyl-3-hydroxy -1, 4-naphthoquinones

    Patent issuer and numberin 2007/IN1474/MUM2007
    Patent dateIssued 2007

    Contributors

    Dr. Pravin C. PatilKrishnacharya Akamanchi
  • Patent titleBisulphite adduct of Donepezil intermediate

    Patent issuer and numberin IN1164/KOL/2010
    Patent dateFiled 2012

    Contributors

    Dr. Pravin C. Patilpurna rayGurvinder Pal SinghHemraj Lande
  • Patent title

    A novel method for synthesis of Parvaquon
    Patent issuer and numberin IN 2678/Mum/2009
    Patent dateFiled 2009

    Contributors

    Dr. Pravin C. PatilKrishnacharya Akamanchi
  • Patent title

    Process for preparation of methyl –(+)-(S)-Alpha-(2-chlorophenyl)-6,7-dihydrothieno [3,2-C] pyridine-5(4H)-acetic acid methyl esters or salts thereof having higher chiral purity and products thereof.
    Patent issuer and numberus US2010/0004453A1

Dr. Pravin has 2 honors2

Honors & Awards

  • honor titleSenior Research Fellowship

    honor dateDec 2007
    honor issuerWorld Bank through TEQIP Programe
  • honor titleJunior Research Fellowship

    honor dateDec 2005
    honor issuerWorld Bank through TEQIP Programe




PATENTS
1. Bisulphite adduct of Donepezil intermediate. Patil, Pravin; Lande, Hemraj; Singh, Gurvinder pal; Ray Purna. Lupin Ltd, From Indian (2010), IN 1164/KOL/2010.
2. Process for preparation of methyl –(+)-(S)-Alpha-(2-chlorophenyl)-6,7-dihydrothieno [3,2-C] pyridine-5(4H)-acetic acid methyl esters or salts thereof having higher chiral purity and products thereof. By Srivasatava, Anita Ranjan; Pawar, Prashant Pandurang; Poojari, Krishna Anand; Patil, Pravin Chaitram; Dalvi, Rajiv Ramchandra. RPG Life Sciences: US2010/0004453 A1.
3. A novel method for the synthesis of 2-alkyl-3-hydroxy -1, 4-naphthoquinones. Patil, Pravin C. and Akamanchi, Krishnacharya G. From Indian (2007), IN 1474/ Mum/ 2007.

AWARDS/FELLOWSHIPS
• Outstanding Performance Year Award (2010-2011) by Lupin Ltd.(Research Park) Pune, India.
• Senior Research Fellowship (2008-2009) by World Bank through TEQIP (Technical Education Quality Improve Programe) at Institute of Chemical Technology, Mumbai, India.
• Junior Research Fellowship (2005-2008) by World Bank through TEQIP (Technical Education Quality Improve Programe) by Institute of Chemical Technology, Mumbai, India.
• Nominated for Best Ph.D. Student in Institute of Chemical Technology, Mumbai, Maharashtra, India for the years 2007-08 and 2009-10.
• Ranked in top 5% in Master (M. Sc.) and Bachelor (B. Sc.) examinations at university level.


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