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Monday, 23 February 2015

Dr. D. Srinivasa Reddy of NCL winner Shanti Swarup Bhatnagar Award 2015

ds.reddy

Dr. D. Srinivasa Reddy
Senior Scientist
Organic Chemistry Division
National Chemical Laboratory
PUNE, INDIA

LINKS
 

 NCL PUNE INDIA

 WEBSITE--http://www.ncl-india.org/



Dr. Srinivasa Reddy of CSIR-NCL bags the 

prestigious Shanti Swarup Bhatnagar Prize



The award comprises a citation, a plaque, a cash prize of Rs 5 lakh
dr













The Shanti Swarup Bhatnagar Prize for the year 2015 in chemical sciences has been awarded to Dr. D. Srinivasa Reddy of CSIR-National Chemical Laboratory (CSIR-NCL), Pune for his outstanding contributions to the area of total synthesis of natural products and medicinal chemistry.
This is a most prestigious award given to the scientists under 45 years of age and who have demonstrated exceptional potential in Science and Technology. The award derives its value from its rich legacy of those who won this award before and added enormous value to Indian Science.
Dr. Reddy will be bestowed with the award at a formal function, which shall be presided over by the honourable Prime Minister. The award, named after the founder director general of Council of Scientific & Industrial Research (CSIR), Dr. Shanti Swarup Bhatnagar, comprises a citation, a plaque, a cash prize of Rs 5 lakh.
Dr. Reddy's research group current interests are in the field of total synthesis and drug discovery by applying medicinal chemistry. He has also been involved in the synthesis of the agrochemicals like small molecules for crop protection. The total synthesis of more than twenty natural products has been achieved in his lab including a sex pheromone that attracts the mealy bugs and has potential use in the crop protection. On the medicinal chemistry front significant progress has been made by his group using a new concept called "Silicon-switch approach" towards central nervous system drugs. Identification of New Chemical Entities for the potential treatment of diabetes and infectious diseases is being done in collaboration with industry partners.
His efforts are evidenced by 65 publications and 30 patents. He has recently received the NASI-Reliance industries platinum jubilee award-2015 for application oriented innovations and the CRSI bronze medal. In addition, he is also the recipient of Central Drug Research Institute award for excellence in the drug research in chemical sciences and scientist of the year award by the NCL Research Foundation in the year 2013. Dr. Reddy had worked with pharmaceutical companies for seven years before joining CSIR-NCL in 2010.




AN INTRODUCTION

Ph.D., University of Hyderabad, 2000 (Advisor: Professor Goverdhan Mehta).

Post-doctoral with Profs. Sergey A. Kozmin(University of Chicago, USA) and Prof.
Jeffrey Aubé (University of Kansas, USA)

Experienced in leading drug discovery programs (Dr. Reddy’s & TATA Advinus – 7
years of pharma experience)

Acquired skills in designing novel small molecules and lead optimization

Experienced in planning and execution of total synthesis of biologically active
molecules with moderate complexity

One of the molecules is currently in human clinical trials.

  

Education










Indian Institute of ScienceIndian Institute of Science











University of Hyderabad

PhD, Chemistry, 
Ph.D., University of Hyderabad, 2000 (Advisor: Professor Goverdhan Mehta).

 
Prof. Goverdhan Mehta





  

Experience




Senior ScientistNational Chemical Laboratory

National Chemical Laboratory

– Present 

http://www.ncl-india.org/




Section HeadAdvinus Therapeutics- A TATA Enterprise

Advinus Therapeutics- A TATA Enterprise
(7 months)
Drug Discovery - Medicinal Chemistry





Group LeaderAdvinus Therapeutics- A TATA Enterprise

Advinus Therapeutics- A TATA Enterprise
(2 years 5 months)
Drug Discovery - Medicinal Chemistry



Research InvestigatorDr. Reddy's Laboratories

Dr. Reddy's Laboratories
(10 months)
Drug Discovery - Medicinal Chemistry




Principal ScientistDr. Reddy's Laboratories

Dr.Reddy's Laboratories Ltd.
(3 years 1 month)
Drug Discovery - Medicinal Chemistry







Postdoc researchUniversity of Kansas

University of Kansas (2 years)
Post-doctoral with Prof. Jeffrey Aubé
(Univ. of Kansas, USA)

 
Jeff Aubé



PostdocresearchUniversity of Chicago

University of Chicago
(1 year)
Post-doctoral with Profs. Sergey A. Kozmin
(University of Chicago,USA)
 Sergey A. Kozmin




Research areas

  • Total Synthesis
  • Medicinal Chemistry
Our group research interests are broadly in total synthesis of biologically active compounds and medicinal chemistry. Current projects include the total synthesis of bioactive natural products such as antiinflammatory agents, antibacterial agents, antimalarial compounds and anti-cancer agents. Targets are chosen for their interesting biological activity and moderate complexity, which drives our creative solutions to their synthesis. Our ability to achieve an efficient synthesis enables us to access sufficient quantities of target molecule for biological profiling and ready access to different analogs that may prove to be more selective and efficacious as a drug-like molecule. We have plans to divert our total synthesis projects into medicinal chemistry projects by simplifying the complex structures. In medicinal chemistry front, our main interest is to use "silicon-switch approach" to discover novel drugs or drug-like molecules with improved pharmacokintetic (PK) and pharmacodynamic (PD) properties.


s reddy ncl
DEC2014 NCL PUNE INDIA
DR ANTHONY WITH DR REDDY


Some pictures of his group


NCL, PUNE



D. Srinivasa Reddy of CSIR-National Chemical Laboratory Pune devised (J. Org. Chem. 201378, 8149. DOI: 10.1021/jo401033j) a cascade protocol of Diels-Alder cycloaddition of 8 to the diene 7 followed by intramolecular aldol condensation, to give the enone 9. Oxidative manipulation followed by methylenation completed the synthesis of the commercially important grapefruit flavor Nootkatone (10).
Abstract Image
A simple and efficient synthesis of functionalized cis-hydrindanes and cis-decalins was achieved using a sequential Diels–Alder/aldol approach in a highly diastereoselective manner. The scope of this method was tested with a variety of substrates and was successfully applied to the synthesis of two natural products in racemic form. The highlights of the present work provide ready access to 13 new cis-hydrindanes/cis-decalins, a protecting group-free total synthesis of an insect repellent Nootkatone, and the first synthesis of a Noreremophilane using the shortest sequence.
A simple and efficient synthesis of functionalized cis-hydrindanes and cis-decalins was achieved using a sequential Diels–Alder/aldol approach in a highly diastereoselective manner. The scope of this method was tested with a variety of substrates and was successfully applied to the synthesis of two natural products in racemic form. The highlights of the present work provide ready access to 13 new cis-hydrindanes/cis-decalins, a protecting group-free total synthesis of an insect repellent Nootkatone, and the first synthesis of a Noreremophilane using the shortest sequence.
(4R*,4aS*,6R*)-4,4a-Dimethyl-6-(prop-1-en-2-yl)-4,4a,5,6,7,8-hexahydronaph thaen-2(3H)-one ((±)-Nootkatone 20)
(±)-Nootkatone 20 (19 mg, 65%). IRυmax(film) 2923, 1668, 1606, 1459 cm–1; 1H NMR (400 MHz, CDCl3) δ 5.77 (s, 1 H), 4.74 (s, 1 H), 4.72(s, 1 H), 2.50 (ddt, J = 15.3, 5.0, 1.8 Hz, 1 H), 2.40–2.24 (m, 4 H), 2.04–1.89 (m, 3 H),1.74 (s, 3 H), 1.40–1.29 (m, 2 H), 1.11 (s, 3 H), 0.96 (d, J = 6.7 Hz, 3 H); 13C NMR (100 MHz, CDCl3) δ 199.9, 170.7, 149.3, 124.8, 109.4, 44.0, 42.2, 40.6, 40.5, 39.5, 33.2, 31.7, 21.0, 17.0, 15.0.
 

Contact



Recent publications
Org. Lett.2013, 16, ASAP article
J. Org. Chem. 2013, 78, 8149
J. Org. Chem. 2013, 78, 6281
Org. Lett. 2013, 15, 1894
Chem. Commun.2013, 49, 3242
Org. Lett.2012, 14, 6222
Org. Biomol. Chem.2012, 10, 5385
J. Diabetes Metab.2013, ASAP article
Tetrahedron Lett.,2012, 53, 6343
RSC. Adv.2012, 2, 3596
Org. Lett.2011, 13, 3690
Tetrahedron Lett.2011, 33, 4313
Bioorg. Med. Chem. Lett.2011, 21, 4913
J. Org. Chem.2011, 76, 963
Org. Biomol. Chem.2011, 9, 744

Patents:
WO2013/054275 A1
WO2013/054366 A1
US8163704B2/2012
WO 2011/048148A2
US 2011/0171159A1
US 2011/0269700A1
US 2011/0230403A



///////////////

UPDATE


New route for Expensive drug Ivacaftor synthesis from CSIR-NCL, Pune, India

Cover image for Vol. 2015 Issue 32

Ivacaftor.svg
IVACAFTOR

Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carb­oxylic Acid Amides and the Expensive Drug Ivacaftor
N. VasudevanGorakhnath R. Jachak and D. Srinivasa Reddy*

Article first published online: 3 NOV 2015
DOI: 10.1002/ejoc.201501048







Abstract
A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop–Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.


REFERENCES

N. Vasudevan, Gorakhnath R. Jachak And D. Srinivasa Reddy, Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carb­oxylic Acid Amides and the Expensive Drug Ivacaftor, Eur. J. Org. Chem., , 0000 (2015), DOI:10.1002/ejoc.201501048.
http://academic.ncl.res.in/publications/index/select-faculty/2015/ocd

Breaking and Making of Rings: A Method for the Preparation …

onlinelibrary.wiley.com › … › Early View
6 days ago – European Journal of Organic Chemistry … 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive …

European Journal of Organic Chemistry – Wiley Online Library

onlinelibrary.wiley.com › … › European Journal of Organic Chemistry
European Journal of Organic Chemistry ….. examples and is successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.

Breaking and making – Wiley Online Library

onlinelibrary.wiley.com › … › Early View › Abstract
6 days ago – … for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug IvacaftorEuropean Journal of Organic Chemistry.


Update dec2015

DR SRINIVASA REDDY gets NASI – Reliance Industries Platinum Jubilee Award (2015) for Application Oriented Innovations in Physical Sciences.


DR REDDY
DR SRINIVASA REDDY  recieving NASI - Reliance Industries Platinum Jubilee Award (2015) for Application Oriented Innovations in Physical Sciences.
Dr. D. Srinivasa Reddy, Senior Scientist, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune – 411 008

AWARD CLICK HERE....LINK

PUNE: Senior scientist of National Chemical Laboratory (NCL), D Srinivasa Reddy has been selected for this year's NASI-Reliance Industries Platinum Jubilee award for the application oriented innovations in the area of physical sciences instituted by the National Academy of Sciences, India (NASI). Two awards each in physical sciences and two in biological sciences are given every year, a statement issued by NCL said.
Manindra Agrawal from Department of Computer Science and Engineering, Indian Institute of Kanpur is the other recipient of this award in physical sciences. Each award carries a plaque and Rs 2 lakh cash.
The award will be presented in the 85th annual session of National Academy of Sciences, India. Reddy's research group interests are in the field of total synthesis and drug discovery by applying medicinal chemistry. He has also been involved in the synthesis of the agrochemicals like small molecules for crop protection, said the statement. The total synthesis of more than 20 natural products has been achieved in his lab including a sex pheromone that attracts the mealy bugs and has potential use in the crop protection.
On the medicinal chemistry front significant progress has been made by his group using a new concept called silicon-switch approach towards central nervous system drugs. Identification of new chemical entities for the potential treatment of diabetes and infectious diseases is being done in collaboration with industry partners.



Some details
The National Academy of Sciences, India (NASI) 5, Lajpatrai Road, Allahabad – 211002 NASI-RELIANCE INDUSTRIES PLATINUM JUBILEE AWARDS FOR THE YEAR 2015 FOR APPLICATION ORIENTED INNOVATIONS COVERING BOTH PHYSICAL AND BIOLOGICAL SCIENCES NASI invites nominations for the NASI-Reliance Industries Platinum Jubilee Awards for APPLICATION ORIENTED INNOVATIONS for the year 2015. The nominee should be an Indian citizen / Overseas Citizen of India working in India and below the age of 50 years as on April 15, 2015. Areas for the Awards – Physical Sciences, including – Chemistry, Engineering, Mathematics, Physics, Electronics, Nanotechnology, Information & Computer Sciences, Earth and Atmospheric Sciences; Biological Sciences, including – Agriculture, Animal and Plant Sciences, Environment, Biotechnology, Biochemistry, Bioprocess Engineering, Bioinformatics, all branches of medical sciences and Nanotechnology. Number and Value of Awards – two in Physical Sciences and two in Biological Sciences each year. Each award carries a Plaque and Rs. 2 lakhs in cash. Nominators and Last Date – All Science Secretaries, Secretary HRD, Director Generals – CSIR, ICMR & ICAR; Directors of IITs, IIITs, National Laboratories, Industries with well recognized R&D units including private research institutions; Vice-Chancellors of all Universities – Central & State; Directors of Indian Institute of Science, Bangalore, AIIMS, New Delhi, PGI’s of Medical Research, Chairman, UGC; Presidents of all Science and Engineering Academies (Engineering, Medical, Agriculture); All Fellows of the NASI. The nomination shall be made in the prescribed format. Twenty (20) copies of the nomination form along with only one soft copy (in CD), complete in all respect with the supporting documents, must reach the Academy latest by April 15, 2015. A candidate may only be nominated once. However, a nomination will remain valid for consideration for 3 years or the age eligibility which ever expires earlier. Selection of the Awardees – As per Regulations of NASI Presentation of the Awards – The presentation of the Awards will be made at the time of 85 th Annual Session of NASI. Details and Nomination form for the award are also available on NASI’s website http://www.nasi.org.in and http://www.nasi.nic.in ................http://www.nasi.org.in/NASI-Reliance%20Industries%20Platinum%20Jubilee%20Awards%202015.pdf
SEE
http://www.nasi.org.in/NASI-Reliance%20Industries%20Platinum%20Jubilee%20Awardees%20(2015).htm
PUNE: Senior scientist at National Chemical Laboratory (NCL) D Srinivasa Reddy has bagged yet another award, the NASI-Reliance Industries Platinum Jubilee award for the year 2015.
This is the second award Reddy has won in a span of less than a fortnight. Earlier, he was selected for the bronze medal presented by the Chemical Research Society of India (CRSI). He has also been a recipient of excellence award from the National Drug Research Institute.
The platinum jubilee award is being conferred for his work in application-oriented innovations in physical sciences category.
Every year, this award recognises two scientists, each working in the fields of physical and biological sciences.
The other scientist who has been awarded in this category is Manindra Agarwal from IIT, Kanpur.
Reddy along with his team has been involved in several high-end research in drug discovery, mainly by applying medicinal chemistry. Other major works he undertook also involve synthesising of agrochemicals meant to be used for crop protection.
He also has vast experience working with various pharmaceutical companies prior to joining NCL in 2010.
The award consists of cash of Rs 2 lakh.

NASI
National Academy of Sciences, India (www.nasi.org.in) was founded in 1930 with the objective to provide a national forum for the scientists to help them publish their research work and discuss the issues for the solutions. NASI-Reliance together give two awards each in the areas of physical and biological sciences for the application oriented innovations started from the year 2006. Areas for the Awards – Physical Sciences, including Chemistry, Engineering, Mathematics, Physics, Electronics, Nanotechnology, Information & Computer Sciences, Earth and Atmospheric Sciences; Biological Sciences, including Agriculture, Animal and Plant Sciences, Environment, Biotechnology, Biochemistry, Bioprocess Engineering, Bioinformatics, all branches of medical sciences and Nanotechnology.


UPDATE.........

Exciting lecture by Dr Srinivasa Reddy at Glenmark research centre, Mahape, Navi mumbai, India, 1 Feb 2016






Exciting lecture by Dr Srinivasa Reddy of NCL pune India, on his achievements in Drug discovery at Glenmark research centre, mahape, Navi mumbai, India, 1 Feb 2016, He is Prestigious recipient of Shanti swaroop Bhatnagar award 2015


WITH Abraham Thomas



Abraham Thomas,  
ME
AND
DR GHARAT




//////////DR SRINIVASA REDDY , NASI - Reliance Industries Platinum Jubilee Award, 2015, Application Oriented Innovations in Physical Sciences,

1 comment:

  1. Excellent work Reddy Garu !!! We are proud of you :) !!!

    ReplyDelete